Publications
Unveiling the Antioxidant Profiling, Cytotoxicity and Wound Healing Potential of Biocompatible Silver Nanoparticles Synthesized Using Solanum melongena
Computational screening of natural inhibitors against Plasmodium falciparum kinases: Toward novel antimalarial therapies
Interleukin-32: a Pandora's box in human immunodeficiency virus infection
Antimicrobial Textiles: Latest Developments and Functional Dimensions
Computational identification of membrane proteins for vaccine design against drug-resistant Moraxella catarrhalis
In vitro investigation of Datura innoxia phytocompounds against Mycobacterium tuberculosis H37Ra strain in association with in silico studiesuberculosis (TB) is a recurrent and progressive bacterial disease caused by Mycobacterium tuberculosis (Mtb), posing a significant challenge globally due to its drug resistance. This study focuses on identifying natural phytocompounds from the plant Datura innoxia (leaves), which is well known for its biologically active metabolites. Initially, the current study employed in vitro analysis of 20 phytocompounds, revealing that the natural compound 9, o-vanillin, exhibited the best minimal inhibitory concentration (MIC) which was 12.5 µg/mL, and minimal bactericidal concentration (MBC) was 50 µg/mL, all other phytocompounds showing remarkable antitubercular activity against the Mtb H37Ra strain. The molecular docking and simulation also validated the strong affinity and stable binding interactions between compound 9 and target protein kinase. The pharmacokinetic analysis highlighted the suitable oral bioavailability and no significant CYP450 inhibition for the lead compound 9, reducing the risk for drug-drug interactions. Moreover, the density functional theory analysis of lead compound 9 demonstrated optimal molecular properties, further contributing to the chemical stability and reactivity. Therefore, these results suggest that D. innoxia contains the potent phytocompound o-vanillin, which possesses antitubercular activity and can potentially be used as a drug against TB. However, future studies will focus on in vivo validation and formulation development for clinical applications.
Computational design of an mRNA vaccine targeting antifungal-resistant Lomentospora prolificans
Dynamics of urinary tract infections: a comprehensive study on antimicrobial susceptibility, virulence profiling and molecular epidemiology of uropathogenic Escherichia coli from Pakistan
Screening of novel therapeutic targets and chimeric vaccine construction against antibiotic-resistant Yersinia Enterocolitica
Discovery of antitubercular potential of trans-3-indoleacrylic acid and its derivatives targeting Mycobacterium tuberculosis: A combined in vitro and in silico investigation
Toll-Like Receptors in Malaria: Gatekeepers of Innate Immunity and Pathogenesis
Aloe vera Phytochemicals as Potential Antibacterial Agents Against Multidrug-Resistant Pseudomonas aeruginosa
A combined in silico and MD simulation approach to discover novel LpxC inhibitors targeting multiple drug resistant Pseudomonas aeruginosa
Preparation, characterization, and biological evaluation of Ocimum basilicum hemicellulose-based composites for wound healing
A Review of In Silico and In Vitro Approaches in the Fight Against Carbapenem-Resistant Enterobacterales
Antifungal Resistance Among Candida Species: Diagnostic and Clinical Challenges in Specialized Cancer Care Hospital of Lahore
Anti-Rheumatic potential of biological DMARDS and protagonistic role of bio-markers in early detection and management of rheumatoid arthritis
In silico identification and characterization of potent laccase inhibitors against Cryptococcus neoformans: A multi-scale computational study
Identifying novel inhibitors against drug-resistant mutant CYP-51 Candida albicans: A computational study to combat fungal infections
Computational Analysis of Ayurvedic Metabolites for Potential Treatment of Drug-Resistant Candida Auris
Advancing the understanding of Naegleria fowleri: Global epidemiology, phylogenetic analysis, and strategies to combat a deadly pathogen
Genotyping and Characterizing Plasmodium falciparum to Reveal Genetic Diversity and Multiplicity of Infection by Merozoite Surface Proteins 1 and 2 (msp-1 and msp-2) and Glutamate-Rich Protein (glurp) Genes
Substrate-Induced Structural Dynamics and Evolutionary Linkage of Siderophore-Iron ABC Transporters of Mycobacterium tuberculosis
Green Synthesis of Silver Nanoparticles Using Doxycycline: Evaluation of Antimicrobial Potential and Organ-specific Toxicity
Estimation and Action Mechanisms of Cinnamon Bark via Oxidative Enzymes and Ultrastructures as Antimicrobial, Anti-biofilm, Antioxidant, Anti-diabetic, and Anticancer Agents
Methicillin-Resistant Staphylococcus aureus among Students: Nasal Carriage Rate, Contributing Factors, and Antimicrobial Susceptibility
Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation
Exploration of the Human Microbiome's Role in Health and Disease through the Lens of Genetics
Preparation and characterization of a ciprofloxacin-loaded nanoparticles incorporated polymeric film dressing
Adenosine A2AR in viral immune evasion and therapy: unveiling new avenues for treating COVID-19 and AIDS
Investigating the Potential of Green-Fabricated Zinc Oxide Nanoparticles to Inhibit the Foodborne Pathogenic Bacteria Isolated from Spoiled Fruits
Genomic Insights into and In Vitro Evaluation of Antimicrobial Combination Therapies for Carbapenem-Resistant Acinetobacter baumannii
The Rising Tide of Antibiotic Resistance: A Study on Extended-Spectrum Beta-Lactamase and Carbapenem-Resistant Escherichia coli and Klebsiella pneumoniae
Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends
A survey-based study of public awareness about COVID-19 infection, severity, reinfection, vaccine acceptance, and government measures in Pakistan
MicroRNA-155, a double-blade sword regulator of innate tuberculosis immunity
Exploring the virulence potential of immune evasion cluster genes in methicillin-resistant Staphylococcus aureus from cancer patients
Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction
The interleukin-10 family: Major regulators of the immune response against Plasmodium falciparum infections
Co-existence of NDM-, aminoglycoside- and fluoroquinolone-resistant genes in carbapenem-resistant Escherichia coli clinical isolates from Pakistan
Association of exogenous factors with molecular epidemiology of Staphylococcus aureus in human oral cavity
Biological Role of Zinc in Liver Cirrhosis: An Updated Review
Effect of tellurite on growth of extensively drug resistant (XDR) Mycobacterium tuberculosis and action on mycobacterial drug efflux pump
Synthesis, Characterization, and Biological Evaluation of Meldrum’s Acid Derivatives: Dual Activity and Molecular Docking Study
Antibacterial efficacy of indigenous Pakistani honey against extensively drug-resistant clinical isolates of Salmonella enterica serovar Typhi: an alternative option to combat antimicrobial resistance
Molecular analysis of Panton-Valentine Leucocidin (pvl) gene among MRSA and MSSA isolates
Antibiotic-Resistant Bacteria, Antimicrobial Resistance Genes, and Antibiotic Residue in Food from Animal Sources: One Health Food Safety Concern
Covalent Organic Frameworks (COFs) as Multi-Target Multifunctional Frameworks
Rubella Virus Infections: A Bibliometric Analysis of the Scientific Literature from 2000 to 2021
Estimation of serum iron, serum lipids and serum liver enzymes in celiac disease patients of Saudi Arabia
Bibliometric Analysis of Publications on the Omicron Variant from 2020 to 2022 in the Scopus Database Using R and VOSviewer
Emergence and dissemination of monkeypox, an intimidating global public health problem
Molecular characterization and antibiogram of the carbapenemase gene variants in clinical strains of Pseudomonas aeruginosa
Multiple Antimicrobial Resistance and Heavy Metal Tolerance of Biofilm-Producing Bacteria Isolated from Dairy and Non-Dairy Food Products
The Molecular Detection of Class B and Class D Carbapenemases in Clinical Strains of Acinetobacter calcoaceticus-baumannii Complex: The High Burden of Antibiotic Resistance and the Co-Existence of Carbapenemase Genes
Perceiving the Concealed and Unreported Pharmacophoric Features of the 5-Hydroxytryptamine Receptor Using Balanced QSAR Analysis
Adenosine A(2A) receptor as a potential target for improving cancer immunotherapy
Protective Effect of Butanolic Fraction of Delphinium brunonianum on Fructose-Mediated Metabolic Alterations in Rats
Antihypertensive and Vasorelaxant Effects of Citrus aurantifolia Linn. Fruit: Proposed Mechanisms
Analysis of diverse β-lactamases presenting high-level resistance in association with OmpK35 and OmpK36 porins in ESBL-producing Klebsiella pneumoniae
Detection of Klebsiella pneumoniae antibiotic-resistant genes: An impending source of multidrug resistance dissemination through raw food
Extraction Optimization of Mucilage from Seeds of Mimosa pudica by Response Surface Methodology
Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation
Prevalence, genotypic distribution and the associated risk factors of Hepatitis C infection in Pakistan pediatric patients
Diagnostic approach to elucidate the efficacy and side effects of direct-acting antivirals in HCV infected patients
Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense
Molecular detection of extensively drug-resistant Salmonella Typhi and carbapenem-resistant pathogens in pediatric septicemia patients in Pakistan - a public health concern
Determination of serum tumor necrosis factor-alpha (TNF-α) levels in metabolic syndrome patients from Saudi population
Molecular epidemiology of extensively-drug resistant Acinetobacter baumannii sequence type 2 co-harboring bla (NDM) and bla (OXA) from clinical origin
Heavy Metal Tolerance Trend in Extended-Spectrum ?-Lactamase Encoding Strains Recovered from Food Samples
Molecular Epidemiology of Extensively Drug-Resistant mcr Encoded Colistin-Resistant Bacterial Strains Co-Expressing Multifarious ?-Lactamases
Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan
Clonal relatedness and plasmid profiling of extensively drug-resistant New Delhi metallo-?-lactamase-producing Klebsiella pneumoniae clinical isolates
Potential Inhibitory Effect of Vitamins Against COVID-19
Molecular analysis of blaSHV, blaTEM, and blaCTX-M in extended-spectrum β-lactamase producing Enterobacteriaceae recovered from fecal specimens of animals
The present danger of New Delhi metallo-β-lactamase: a threat to public health
COVID-19 and comorbidities: Deleterious impact on infected patients
Emergence of plasmid-mediated mcr genes from Gram-negative bacteria at the human-animal interface
Covid-19 Pandemic: Through the Lens of Science, a Painstaking Review
Current trends in multidrug-resistant AmpC beta-lactamase producing Enterobacter cloacae isolated from a tertiary care hospital
Effective Immune Functions of Micronutrients against SARS-CoV-2
Intelligent Mechanisms of Macrophage Apoptosis Subversion by Mycobacterium
Human cytomegalovirus-encoded MicroRNAs: A master regulator of latent infection
Antibiogram and recent incidence of multi-drug resistant carbapenemase producing Escherichia coli isolated from paediatric patients
Determination of bacterial profile and spectrum of antimicrobial drug resistance in pediatric wound infections
Methicillin and inducible clindamycin-resistant Staphylococcus aureus isolated from postoperative wound samples
Molecular Detection of blaIMP Genes in Metallo-Beta-Lactamase Producing Clinical Gram-Negative Isolates
Resistance mechanisms and population structure of highly drug resistant Klebsiella in Pakistan during the introduction of the carbapenemase NDM-1
Bacterial contamination of Pakistani currency notes from hospital and community sources
Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan