Publications
Interleukin-32: a Pandora’s box in human immunodeficiency virus infection
Interleukin-32: a Pandora's box in human immunodeficiency virus infection
In vitro investigation of Datura innoxia phytocompounds against Mycobacterium tuberculosis H37Ra strain in association with in silico studiesuberculosis (TB) is a recurrent and progressive bacterial disease caused by Mycobacterium tuberculosis (Mtb), posing a significant challenge globally due to its drug resistance. This study focuses on identifying natural phytocompounds from the plant Datura innoxia (leaves), which is well known for its biologically active metabolites. Initially, the current study employed in vitro analysis of 20 phytocompounds, revealing that the natural compound 9, o-vanillin, exhibited the best minimal inhibitory concentration (MIC) which was 12.5 µg/mL, and minimal bactericidal concentration (MBC) was 50 µg/mL, all other phytocompounds showing remarkable antitubercular activity against the Mtb H37Ra strain. The molecular docking and simulation also validated the strong affinity and stable binding interactions between compound 9 and target protein kinase. The pharmacokinetic analysis highlighted the suitable oral bioavailability and no significant CYP450 inhibition for the lead compound 9, reducing the risk for drug-drug interactions. Moreover, the density functional theory analysis of lead compound 9 demonstrated optimal molecular properties, further contributing to the chemical stability and reactivity. Therefore, these results suggest that D. innoxia contains the potent phytocompound o-vanillin, which possesses antitubercular activity and can potentially be used as a drug against TB. However, future studies will focus on in vivo validation and formulation development for clinical applications.
In vitro antiviral activities of thymol and Limonin against influenza a viruses and SARS-CoV-2
Identification and evaluation of pyrimidine based CDK6 inhibitors against glioblastoma using integrated computational approaches
Identification and evaluation of pyrimidine based CDK6 inhibitors against glioblastoma using integrated computational approaches.
Innovative strategies in the diagnosis and treatment of liver cirrhosis and associated syndromes
In silico identification and characterization of potent laccase inhibitors against Cryptococcus neoformans: A multi-scale computational study
In silico identification and characterization of potent laccase inhibitors against Cryptococcus neoformans: A multi-scale computational study
Identifying novel inhibitors against drug-resistant mutant CYP-51 Candida albicans: A computational study to combat fungal infections
Identifying novel inhibitors against drug-resistant mutant CYP-51 Candida albicans: A computational study to combat fungal infections
Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss
Innovative Diagnostic Approaches and Challenges in the ManagementofHIV:Bridging Basic Science and Clinical Practice
Identification of Serum-Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV-HCC: A Cross-Sectional Study
Investigating the in vitro antibacterial, antibiofilm, antioxidant, anticancer and antiviral activities of zinc oxide nanoparticles biofabricated from Cassia javanica
Investigating the in vitro antibacterial, antibiofilm, antioxidant, anticancer and antiviral activities of zinc oxide nanoparticles biofabricated from Cassia javanica
Investigating the Potential of Green-Fabricated Zinc Oxide Nanoparticles to Inhibit the Foodborne Pathogenic Bacteria Isolated from Spoiled Fruits
Implications of Temperature and Prey Density on Predatory Mite Amblyseius swirskii (Acari: Phytoseiidae) Functional Responses
Isolation, characterization, and preliminary application of three Vibrio phages in controlling Vibrio alginolyticus
In vitro anti-cancer and antimicrobial effects of manganese oxide nanoparticles synthesized using the Glycyrrhiza uralensis leaf extract on breast cancer cell lines
In vitro anti-cancer and antimicrobial effects of manganese oxide nanoparticles synthesized using the Glycyrrhiza uralensis leaf extract on breast cancer cell lines
Identification and dynamics of novel scaffolds against Enterococcus faecium serine hydroxymethyltransferase enzyme: a potential target for antibiotics development
Identification and Functional Characterization of Mutation in FYCO1 in Families with Congenital Cataract
Impact of glycogen synthase kinase-3ß inhibition on rats’ temporomandibular joint collageninduced rheumatoid arthritis with correlation to miRNA-155/miRNA-24 expression
Identification and Functional Characterization of Mutation in FYCO1 in Families with Congenital Cataract
Identification and In Silico Analysis of a Novel Mutation of MAN2B1 Gene in Congenital Family with Alpha-Mannosidosis from Pakistan
Impact of Methionine Synthase Reductase Polymorphisms in Chronic Myeloid Leukemia Patients
In Vitro, Molecular Docking and In Silico ADME/Tox Studies of Emodin and Chrysophanol against Human Colorectal and Cervical Carcinoma
Impact of Methionine Synthase Reductase Polymorphisms in Chronic Myeloid Leukemia Patients
Impact of Methionine Synthase Reductase Polymorphisms in Chronic Myeloid Leukemia Patients
In Vitro Anti-Proliferative, and Kinase Inhibitory Activity of Phenanthroindolizidine Alkaloids Isolated from Tylophora indica
Increasing atmospheric CO2 differentially supports arsenite stress mitigating impact of arbuscular mycorrhizal fungi in wheat and soybean plants
In Vitro Assessment of Antistaphylococci, Antitumor, Immunological and Structural Characterization of Acidic Bioactive Exopolysaccharides from Marine Bacillus Cereus Isolated from Saudi Arabia
Innovating the Synergistic Assets of ?-amino Butyric Acid (BABA) and Selenium Nanoparticles (SeNPs) in Improving the Growth, Nitrogen Metabolism, Biological Activities, and Nutritive Value of Medicago interexta Sprouts
Investigation of the Bacterial Contamination and Antibiotic Susceptibility Profile of Bacteria Isolated from Bottled Drinking Water
Interactive Impact of Biochar and Arbuscular Mycorrhizal on Root Morphology, Physiological Properties of Fenugreek (Trigonella foenum-graecum L.) and Soil Enzymatic Activities
Improved Mineral Acquisition, Sugars Metabolism and Redox Status after Mycorrhizal Inoculation Are the Basis for Tolerance to Vanadium Stress in C3 and C4 Grasses
Insight into the emerging role of SARS-CoV-2 nonstructural and accessory proteins in modulation of multiple mechanisms of host innate defense
Immune expression of Estrogen receptors Alpha in Oral mucosa among Sudanese patients with Breast cancer
Influence of elevated CO2 on nutritive value and health-promoting prospective of three genotypes of Alfalfa sprouts (Medicago Sativa)
Interactive effects of mercuric oxide nanoparticles and future climate CO2 on maize plant
Intelligent Mechanisms of Macrophage Apoptosis Subversion by Mycobacterium
In Silico analysis of SIGMAR1 gene causing distal hereditary motor neuropathy in a Pakistani family
Identification of Plasmodium falciparum isolates lacking histidine-rich protein 2 and 3 in Eritrea