Publications
Identification of novel thiazolyl-1,2,3-triazole hybrids as potent VEGFR-2 inhibitors for breast cancer treatment
Resolving Spectral Overlaps in Anti-Parkinson Drug Combinations: A Green Spectrophotometric Approach for Entacapone Determination
One-pot synthesis of Au/GO nanozymes: enhanced catalytic activity via in situ chemical reduction
Pyrazole/pyrimidine derivatives endowed with azobenzenes as dual EGFR T790M and VEGFR-2 inhibitors: anticancer, docking, synthesis, design and ADMET assessments
Bridging the gap with amide linkers: rational design, synthesis, and multi-target evaluation of sulfonamide/acetamide-NSAID hybrids as dual COX-2/5-LOX inhibitors
Statistically optimized orodispersible film loaded with Febuxostat nanosuspension to enhance oral bioavailability
Formulation Design of Glucuronoxylan-Based Stimuli-Responsive Microparticles for Zero-Order Drug Delivery
Thiazolidinedione-Based Dual Inhibitors of α-Amylase and Aldose Reductase: Design, In Vitro Evaluation, and In Vivo Hypoglycemic Activity
Statistically optimized orodispersible film loaded with Febuxostat nanosuspension to enhance oral bioavailability
OpenFieldAI – New Open-Source AI Based Software for Tracking Rodents and Training Open Field Test Models
Interleukin-32: a Pandora’s box in human immunodeficiency virus infection
Chitosan/polyacrylic acid nanogel-mediated delivery system for cancer treatment: Design, synthesis, ADMET, docking of thiazole derivatives as dual inhibitors of VEGFR-2 and EGFRT790M
Targeting drug-resistant cancers: in silico repurposing of the cholesterol-lowering drug Ezetimibe for selective inhibition of aldo-keto reductase 1B10 (AKR1B10)
Targeting drug-resistant cancers: in silico repurposing of the cholesterol-lowering drug Ezetimibe for selective inhibition of aldo-keto reductase 1B10 (AKR1B10)
Ferulic acid mitigates 3-Nitropropionic acid-induced Huntington’s disease via modulation of Nrf2/HO-1, TLR4/NF-κB, and SIRT1/p53 signaling pathways
Assembling of phenyl substituted halogens in the C3-position of substituted isatins by mono wave assisted synthesis: development of a new class of monoamine oxidase inhibitors.
Assessment of Healthcare Professionals’ and Students’ Perspectives and Intentions for Raising Public Awareness and Comprehension of Antimicrobial Resistance
Identification of Microbial-Based Natural Products as Potential CYP51 Inhibitors for Eumycetoma Treatment: Insights from Molecular Docking, MM-GBSA Calculations, ADMET Analysis, and Molecular Dynamics Simulations
Identification of Bacterial Oligopeptidase B Inhibitors from Microbial Natural Products: Molecular Insights, Docking Studies, MD Simulations, and ADMET Predictions
synthesis and characterization of novel pyrazoline derivatives as dual α-amylase /α-glucosidase inhibitors: molecular modeling and kinetic study
Pharmacophore-based virtual screening and in silico investigations of small molecule library for discovery of human hepatic ketohexokinase inhibitors for the treatment of fructose metabolic disorders
Pharmacophore-based virtual screening and in silico investigations of small molecule library for discovery of human hepatic ketohexokinase inhibitors for the treatment of fructose metabolic disorders
Discovery of 1-phenyl-1,2,3-triazole ureas as dual VEGFR-2/JNK-1 type II kinase inhibitors targeting pancreatic cancer
Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies
Exploring Punicalagin Potential Against Cancers: A Comprehensive Review
Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
In silico development of potential InhA inhibitors through 3D-QSAR analysis, virtual screening and molecular dynamics
Isatin derived morpholine and piperazine derivatives as acetylcholinesterase inhibitors
Recent Perspectives on Anticancer Potential of Coumarin Against Different Human Malignancies: An Updated Review
Molecular docking, free energy calculations, ADMETox studies, DFT analysis, and dynamic simulations highlighting a chromene glycoside as a potential inhibitor of PknG in Mycobacterium tuberculosis
Olea europaea L. cv. Nepal Leaf Extract Alleviates Dyslipidemia and Inflammation Related to Obesity in Rabbits: A Network Pharmacology Approach Revealing Effective Antihyperlipidemic Bioactive Compounds
Triazole-Linked Thiazolidinedione-Benzothiazole Hybrids: Design and Biological Evaluation as AChE Inhibitors
New phenylpiperazine-thiazolidine-2,4-dione hybrids targeting MAO inhibition: Synthesis, biological evaluation, kinetic study and in silico insights
Synthesis and mechanistic insights of Coumarinyl-Indolinone hybrids as potent inhibitors of Leishmania major
Examining Prenylated Xanthones as Potential Inhibitors Against Ketohexokinase C Isoform for the Treatment of Fructose-Driven Metabolic Disorders: An Integrated Computational Approach
Biosynthesized zinc oxide nanoparticles: Multifunctional potential applications in anticancer, antibacterial, and B. subtilis DNA gyrase docking
Antileishmanial and Antitrypanosomal Trends of Synthetic Tetralone Derivatives
Microbial-based natural products as potential inhibitors targeting DNA gyrase B of Mycobacterium tuberculosis:anin silico study
Microwave-assisted, sulfhydryl-modified β-cyclodextrin-silymarin inclusion complex: A diverse approach to improve oral drug bioavailability via enhanced mucoadhesion and permeation
Repurposing FDA-Approved Drugs for Eumycetoma Treatment: Homology Modeling and Computational Screening of CYP51 Inhibitors
Repurposing FDA-Approved Drugs for Eumycetoma Treatment: Homology Modeling and Computational Screening of CYP51 Inhibitors
New class of thio/semicarbazidebased benzyloxy derivatives as selective class of monoamine oxidase-B inhibitors
Biological activity and chemical characteristics studies of new oligomannose produced by Erwinia gerundensis
Design, Synthesis, Pharmacological Evaluation of Quinazolin-4(3H)-Ones Bearing Urea Functionality as Potential VEGFR-2 Inhibitors
Computational investigations of flavonoids as ALDH isoform inhibitors for treatment of cancer
Computational investigations of flavonoids as ALDH isoform inhibitors for treatment of cancer
Assessment of perspectives, knowledge and attitude about antibiotic use and resistance in Sudanese population
Unveiling the Anticancer Potential: Computational Exploration of Nitrogenated Derivatives of (+)-Pancratistatin as Topoisomerase I Inhibitors
Unveiling the Anticancer Potential: Computational Exploration of Nitrogenated Derivatives of (+)-Pancratistatin as Topoisomerase I Inhibitors
Recent progress in synthetic and natural COMT inhibitors for neurological disorders
MAO-B Inhibitor (2E)-3-(4-Bromophenyl)-1-(1H-indol-3-yl) prop-2-en-1-one as a Neuroprotective Agent Against Alzheimer’s Disease
Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations
Discerning of isatin-based monoamine oxidase (MAO) inhibitors for neurodegenerative disorders by exploiting 2D, 3D-QSAR modelling and molecular dynamics simulation
Emerging therapeutics: The imidazo[1,2-b]pyridazine scaffold as a novel drug candidate for eumycetoma, a neglected tropical disease
A superporous and pH-sensitive hydrogel from Salvia hispanica (chia) seeds: stimuli responsiveness, on–off switching, and pharmaceutical applications
Flaxseed (Linum usitatissimum) mucilage: A versatile stimuli–responsive functional biomaterial for pharmaceuticals and healthcare
α-Amylase enzyme inhibition relevant to type II diabetes by using functional yogurt with Cinnamomum verum and Stevia rebaudiana
A comprehensive Review of the molecular dynamics, study of chalcones,coumarins,and chromes as selective MAO-B inhibitor
Antioxidant, anticancer, and anti-inflammatory potential of Moringa seed and Moringa seed oil: A comprehensive approach
Impact of Some Natural and Artificial Sweeteners Consumption on Different Hormonal Levels and Inflammatory Cytokines in Male Rats: In Vivo and In Silico Studies
DOI: https://doi.org/10.1021/acsomega.4c01250?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as
A literature review on pharmacological aspects, docking studies, and synthetic approaches of quinazoline and quinazolinone derivatives
Improving plant adaptation to soil antimony contamination: the synergistic contribution of arbuscular mycorrhizal fungus and olive mill waste
Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends
Flavonostilbenes natural hybrids from Rhamnoneuron balansae as potential antitumors targeting ALDH1A1: molecular docking, ADMET, MM-GBSA calculations and molecular dynamics studies
Chalcones with N‐Methylpiperazine Moiety: Synthesis, Monoamine Oxidase Inhibition, Neuroprotective Effect and Computer Simulation Study
Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure–activity relationship, and prospects for clinical advancement
Platinum-based targeted chemotherapies and reversal of cisplatin resistance in non-small cell lung cancer (NSCLC)
Development, optimization and characterization of cisplatin loaded cubosomes for human lung carcinoma
Targeting GABA receptors with chalcone derivative compounds, what is the evidence?
Role of Probiotics against Human Cancers, Inflammatory Diseases, and Other Complex Malignancies
Machine learning driven web-based app platform for the discovery of monoamine oxidase B inhibitors
Fabrication and optimization of febuxostat-loaded chitosan nanocarriers for better pharmacokinetics profile
Prospects of Artificial Intelligence in the Improvement of Healthcare Professions: A Review
A structure-based approach to explore novel COX-2 inhibitors using pharmacophore modelling, 3D-QSAR analysis, virtual screening and dynamics simulation study
Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents
Anti-inflammatory effect of 3-fluorophenyl pyrimidinylimidazo[2,1-b]thiazole derivatives as p38α inhibitors
Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction
Anti-inflammatory effect of 3-fluorophenyl pyrimidinylimidazo[2,1-b] thiazole derivatives as p38α inhibitors
New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study
Introducing of novel class of pyrano[2,3-c]pyrazole-5-carbonitrile analogs with potent antimicrobial activity, DNA gyrase inhibition, and prominent pharmacokinetic and CNS toxicity profiles supported by molecular dynamic simulation
Discovery of Novel Tetramethylpyrazine Containing Chalcone Derivatives as Anti-Inflammatory Agents
Polysaccharide-Based Hydrogel from Seeds of Artemisia vulgaris: Extraction Optimization by Box–Behnken Design, pH-Responsiveness, and Sustained Drug Release
Synthesis, Antimicrobial, and Anticancer Activities of Novel Nitrofuran Derivatives
Flavonostilbenes natural hybrids from Rhamnoneuron balansae as potential antitumors targeting ALDH1A1: molecular docking, ADMET, MM-GBSA calculations and molecular dynamics studies
Halogenated class of oximes as a new class of monoamine oxidase-B inhibitors for the treatment of Parkinson's disease: Synthesis, biochemistry, and molecular dynamics study
Mental Health and Coping Strategies among University Staff during the COVID-19 Pandemic: A Cross–Sectional Analysis from Saudi Arabia
Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach
Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies Mohamed E. Shaker,Hesham A. M. Goma,Izzeddin Alsalahat,Nadia A. A. Elkanzi,Amany A. Azouz,Mohamed Sadek Abdel-Bakky, show all Pages 1804-1817 | Received 10 May 2023, Accepted 27 Nov 2023, Published online: 28 Dec 2023 Cite this article https://doi.org/10.1080/07391102.2023.2293257 CrossMark LogoCrossMark Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days Full Article Figures & data References Supplemental Citations Metrics Reprints & Permissions Read this article Abstract NSAIDs represent a mainstay in pain and inflammation suppression, and their actions are mainly based on inhibiting COX-1 and COX-2 enzymes. Due to the adverse effects of these drugs, especially on the stomach and heart, scientists efforts have been directed to manufacture selective COX-2 without cardiovascular side effects and with minimal effects on the stomach. The cardiovascular side effects are thought to be related to the chemical composition rather than mechanism of action of these drugs. Novel pyridopyrimidines, 9a-j, were prepared and their chemical structures were confirmed by NMR, mass and IR Spectra, and elemental analysis. The effect of the 9a-j compounds on COX-1 and COX-2 was assessed and it was found that 2-hydrazino-5-(4-methoxyphenyl)-7-phenyl-3H-pyrido[2,3-d)pyrimidin-4-one (9d) was the most potent COX-2 inhibitor (IC50 = 0.54 uM) compared to celecoxib (IC50 = 1.11 uM) with selectivity indices of 6.56 and 5.12, respectively. The in vivo inhibition of paw edema of novel compounds 9a-j was measured using carrageenan-induced paw edema method, and that 2-hydrazino-5-(4-methoxyphenyl)-7-phenyl-3H-pyrido[2,3-d)pyrimidin-4-one (9d) showed the best inhibitory activity in comparison with the other compounds and celecoxib. The gastroprotective effect of the potent derivatives 9d, 9e, 9f, 9 g and 9h was investigated. 2-Hydrazino-5-(4-methoxyphenyl)-7-phenyl-3H-pyrido[2,3-d)pyrimidin-4-one (9d) and 7-(chlorophenyl)-hydrazino-5-(4-methoxyphenyl)-3H-pyrido[2,3-d)pyrimidin-4-one (9e) showed ulcer indices comparable to celecoxib (1 and 0.5 vs 0.5, respectively). Docking studies were carried out and they confirmed the mechanistic action of the designed compounds Keywords: COXs inhibitorsanti-inflammatorycelecoxibNSAIDspyridopyrimidines Disclosure statement No potential conflict of interest was reported by the author(s). Additional information Funding This research was funded by the Deanship of Scientific Research at Jouf University, Saudi Arabia through a research grant group to ME Shaker (DSR-2022-RG-0149). Share Related research People also read Recommended articles Cited by 5 Information for Authors R&D professionals Editors Librarians Societies Open access Overview Open journals Open Select Dove Medical Press F1000Research Opportunities Reprints and e-prints Advertising solutions Accelerated publication Corporate access solutions Help and information Help and contact Newsroom All journals Books Keep up to date Register to receive personalised research and resources by email Sign me up Taylor and Francis Group Facebook pageTaylor and Francis Group X Twitter pageTaylor and Francis Group Linkedin page Taylor and Francis Group Youtube pageTaylor and Francis Group Weibo page Copyright © 2025Informa UK Limited Privacy policy Cookies Terms & conditions Accessibility Registered in England & Wales No. 01072954 5 Howick Place | London | SW1P 1WG Taylor and Francis Group PDF Help
Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges
Urachal carcinoma: The journey so far and the road ahead
Phthalazone tethered 1,2,3-triazole conjugates: In silico molecular docking studies, synthesis, in vitro antiproliferative, and kinase inhibitory activities
Genetic Structure of Cucumber Mosaic Virus From Natural Hosts in Nigeria Reveals High Diversity and Occurrence of Putative Novel Recombinant Strains
Impact of Dietary Egg Yolk IgY Powder on Behavior, Meat Quality, Physiology, and Intestinal Escherichia coli Colonization of Broiler Chicks
Recommended and verified stability indicating GC–MS procedures for green separation of quaternary mixture of naphazoline, ephedrine, methylparaben, and naphazoline impurity
Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation
Turning down PI3K/AKT/mTOR signalling pathway by natural products: an in silico multi-target approach
Turning down PI3K/AKT/mTOR signalling pathway by natural products: an in silico multi-target approach
Phthalazone tethered 1,2,3-triazole conjugates: In silico molecular docking studies, synthesis, in vitro antiproliferative, and kinase inhibitory activities
Berberine: a comprehensive Approach to combat human maladies
In vitro and in vivo evaluation of clarithromycin solid dispersion prepared by spray-drying
Synthesis, Characterization, and Biological Evaluation of Meldrum’s Acid Derivatives: Dual Activity and Molecular Docking Study
Targeting Some Key Metalloproteinases by Nano-Naringenin and Amphora coffeaeformis as a Novel Strategy for Treatment of Osteoarthritis in Rats
Development of Isopropyl-Tailed Chalcones as a New Class of Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disorder
A First Report on Side-Effects of COVID-19 Vaccines among General Population in Sudan: A Cross-Sectional Analysis
A First Report on Side-Effects of COVID-19 Vaccines among General Population in Sudan: A Cross-Sectional Analysis
Phytochemical profile and pro-healthy properties of Terminalia chebula: A comprehensive review
New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study
New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study
The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations
Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents
Covalent Organic Frameworks (COFs) as Multi-Target Multifunctional Frameworks
Synthetic Approaches and Pharmacological Attributes of Benzosuberone Skeleton
Introduction of benzyloxy pharmacophore into aryl/ heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
Discovery of novel natural products as dual MNK/PIM inhibitors for acute myeloid leukemia treatment: Pharmacophore modeling, molecular docking, and molecular dynamics studies
Metal-Organic Framework Based Drug Delivery for Alzheimer' Therapy and Clinical Progress
Novel N-methylsulfonyl-indole derivatives: Biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks
Two dimensional-QSAR and molecular dynamics studies of a selected class of aldoxime- and hydroxy-functionalized chalcones as monoamine oxidase-B inhibitors
Design, Synthesis, Molecular Modeling, and Anticancer Evaluation of New VEGFR-2 Inhibitors Based on the Indolin-2-One Scaffold
Chemical characteristics and targeted encapsulated Cordia myxa fruits extracts nanoparticles for antioxidant and cytotoxicity potentials
In Vitro Anti-Proliferative, and Kinase Inhibitory Activity of Phenanthroindolizidine Alkaloids Isolated from Tylophora indica
Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights
Olive Oil/Pluronic Oleogels for Skin Delivery of Quercetin: In Vitro Characterization and Ex Vivo Skin Permeability
Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders
Computational and Molecular Docking Studies of New Benzene Sulfonamide Drugs with Anticancer and Antioxidant Effects
Development and assessment of phospholipid-based luteolin-loaded lipid nanocapsules for skin delivery
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights
An insight into the multifunctional role of ghrelin and structure activity relationship studies of ghrelin receptor ligands with clinical trials
Bibliometric Analysis of Publications on the Omicron Variant from 2020 to 2022 in the Scopus Database Using R and VOSviewer
Design, Synthesis, In Vitro Biological Activity Evaluation and Stabilized Nanostructured Lipid Carrier Formulation of Newly Synthesized Schiff Bases-Based TMP Moieties
Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight
Emergence and dissemination of monkeypox, an intimidating global public health problem
Formulation and Evaluation of Hydroxypropylmethylcellulose-dicyclomine Microsponges for Colon Targeted Drug Delivery: In Vitro and In Vivo Evaluation
Nanotherapeutics for Alzheimer's Disease with Preclinical Evaluation and Clinical Trials: Challenges, Promises and Limitations
Consequences of Antipsychotic Medications on Mental Health
Efects of radiation exposure on brain health: a state of the art and new challenges
Nanoparticle-based therapeutic approaches for wound healing: a review of the state-of-the-art
Development of bromo- and fluoro-based α, β-unsaturated ketones as highly potent MAO-B inhibitors for the treatment of Parkinson's disease
Chitosan-Functionalized-Graphene Oxide (GO@CS) Beads as an Effective Adsorbent to Remove Cationic Dye from Wastewater
High-Pressure Metal-Free Catalyzed One-Pot Two-Component Synthetic Approach for New 5-Arylazopyrazolo[3,4-b]Pyridine Derivatives
Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors
Wound Healing and Antioxidant Properties of Launaea procumbens Supported by Metabolomic Profiling and Molecular Docking
New Sulfamethoxazole Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, Cytotoxic Activity and Molecular Modeling
COVID-19 Challenge: A Quest for Effective Vaccine Strategies Against Circulating and Emerging SARS-CoV-2 Variants
Preventive Effects of Mandarin Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin on Acetaminophen-Induced Hepatonephrotoxicity in Wistar Rats
Nanocomposite of gold nanoparticles@nickel disulfide-plant derived carbon for molecularly imprinted electrochemical determination of favipiravir
Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats
LC/MS Profiling and Gold Nanoparticle Formulation of Major Metabolites from Origanum majorana as Antibacterial and Antioxidant Potentialities
Synthesis and evaluation of novel arylisoxazoles linked to tacrine moiety: in vitro and in vivo biological activities against Alzheimer’s disease
Fabrication, In Vitro and In Vivo Evaluation of Non-Ordered Mesoporous Silica-Based Ternary Solid Dispersions for Enhanced Solubility of Flurbiprofen
Perceiving the Concealed and Unreported Pharmacophoric Features of the 5-Hydroxytryptamine Receptor Using Balanced QSAR Analysis
Nanomedicine: Advancement in healthcare
An Overview of Tetramethylpyrazine (Ligustrazine) and its Derivatives as Potent Anti-Alzheimer’s Disease Agents
Preparation, Characterization of Pregabalin and Withania coagulans Extract-Loaded Topical Gel and Their Comparative Effect on Burn Injury
Development of a Novel Class of Pyridazinone Derivatives as Selective MAO-B Inhibitors
Design, Synthesis and Cytotoxic Activity Evaluation of Newly Synthesized Amides-Based TMP Moiety as Potential Anticancer Agents over HepG2 Cells
Nanomedicine Penetration to Tumor: Challenges, and Advanced Strategies to Tackle This Issue
Azides in the Synthesis of Various Heterocycles
Development of bromo- and fluoro-based α, β-unsaturated ketones as highly potent MAO-B inhibitors for the treatment of Parkinson’s disease
Assessing the Synergistic Activity of Clarithromycin and Therapeutic Oils Encapsulated in Sodium Alginate Based Floating Microbeads
Design, Synthesis and Anticancer Profile of New 4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-amine-Linked Sulfonamide Derivatives with V600EBRAF Inhibitory Effect
Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution
On dynamics of an eco-epidemics system incorporating fractional operators of singular and nonsingular types
A new green approach for the reduction of consumed solvents and simultaneous quality control analysis of several pharmaceuticals using a fast and economic RP-HPLC method; a case study for a mixture of piracetam, ketoprofen and omeprazole drugs
Optimization of pyrazolo[1,5-a]pyrimidine based compounds with pyridine scaffold: Synthesis, biological evaluation and molecular modeling study
Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations
Design, Synthesis, In Vitro Biological Activity Evaluation and Stabilized Nanostructured Lipid Carrier Formulation of Newly Synthesized Schiff Bases-Based TMP Moieties
Protective effect of butanolic fraction of Delphinium brunonianum on fructose mediated metabolic alterations in rats
Efficiency of Multiple Extraction Solvents on Antioxidant, Cytotoxic, and Phytotoxic Potential of Taraxacum officinale (L.) Weber ex F.H. Wigg. from Poonch Valley, Azad Kashmir, Pakistan
Antihypertensive and vasorelaxant effects of Citrus aurantifolia Linn. fruit: Proposed mechanisms
Chitosan Silver and Gold Nanoparticle Formation Using Endophytic Fungi as Powerful Antimicrobial and Anti-Biofilm Potentialities
The nutraceutical properties and health benefits of pseudocereals: a comprehensive treatise
In Vitro Anti-Proliferative, and Kinase Inhibitory Activity of Phenanthroindolizidine Alkaloids Isolated from Tylophora indica
Synthesis of pH sensitive cross linked basil seed gum/acrylic acid hydrogels by free redical copolymerization technique for sustained delivery of captopril
In Vitro and Biological Characterization of Dexamethasone Sodium Phosphate Laden pH-Sensitive and Mucoadhesive Hydroxy Propyl β-Cyclodextrin-g-poly(acrylic acid)/Gelatin Semi-Interpenetrating Networks
Extraction optimization of mucilage from seeds of Mimosa pudica by response surface methodology
Exploration of the Detailed Structure–Activity Relationships of Isatin and Their Isomers As Monoamine Oxidase Inhibitors
Investigation of Chemical Compositions and Biological Activities of Mentha suaveolens L. from Saudi Arabia
Novel Pyridinium Based Ionic Liquid Promoter for Aqueous Knoevenagel Condensation: Green and Efficient Synthesis of New Derivatives with Their Anticancer Evaluation
Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
Metal complexation of arabinoxylan engenders a smart material offering pH, solvents, and salt responsive on-off swelling with potential of sustained drug delivery
Metal Complexation of Arabinoxylan Engenders a Smart Material Offering pH, Solvents, and Salt Responsive On–Off Swelling with the Potential for Sustained Drug Delivery
Synthesis, Characterization, Functionalization and Bio-Applications of Hydroxyapatite Nanomaterials: An Overview
Synthesis and Characterization of Antibiotic–Loaded Biodegradable Citrate Functionalized Mesoporous Hydroxyapatite Nanocarriers as an Alternative Treatment for Bone Infections
Knowledge, Attitudes and Practices of Pharmacogenomics Among Senior Pharmacy Students: A Cross Sectional Study from Punjab, Pakistan
Prunus Armeniaca Gum-Alginate Polymeric Microspheres to Enhance the Bioavailability of Tramadol Hydrochloride: Formulation and Evaluation
A meta-analysis showing the effect of surgical site wound infections and associated risk factors in neonatal surgeries
Review of the Recent Advances in Electrospun Nanofibers Applications in Water Purification
Emerging Nanotherapeutic Approaches to Overcome Drug Resistance in Cancers with Update on Clinical Trials
Antibacterial and Wound-Healing Activities of Statistically Optimized Nitrofurazone- and Lidocaine-Loaded Silica Microspheres by the Box–Behnken Design
Recent Progress and Potential Biomedical Applications of Electrospun Nanofibers in Regeneration of Tissues and Organs
Exploring the Prominent and Concealed Inhibitory Features for Cytoplasmic Isoforms of Hsp90 Using QSAR Analysis
Synthesis and evaluation of new chalcones and oximes as anticancer agents
Electrical Stability and Piezoresistive Sensing Performance of High Strain-Range Ultra-Stretchable CNT-Embedded Sensors
Biological investigation of N-methyl thiosemicarbazones as antimicrobial agents and bacterial carbonic anhydrases inhibitors
Design, synthesis, and biological evaluation of novel pyridodipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells
Pharmacological evaluation of anti-arthritic potential of terpinen-4-ol using in vitro and in vivo assays
Cubosomes as an emerging platform for drug delivery: a state-of-the-art review
Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells
Pioglitazone Synthetic Analogue Ameliorates Streptozotocin-Induced Diabetes Mellitus through Modulation of ACE 2/Angiotensin 1–7 via PI3K/AKT/mTOR Signaling Pathway
Development and Characterization of Gentamicin-Loaded Arabinoxylan-Sodium Alginate Films as Antibacterial Wound Dressing
Nanomaterials Aiming to Tackle Antibiotic-Resistant Bacteria
The Chemical Profiling, Docking Study, and Antimicrobial and Antibiofilm Activities of the Endophytic fungi Aspergillus sp. AP5
Conjugated Dienones from Differently Substituted Cinnamaldehyde as Highly Potent Monoamine Oxidase-B Inhibitors: Synthesis, Biochemistry, and Computational Chemistry
Assessment of Nasal-Brain-Targeting Efficiency of New Developed Mucoadhesive Emulsomes Encapsulating an Anti-Migraine Drug for Effective Treatment of One of the Major Psychiatric Disorders Symptoms
Design, Molecular Docking, Synthesis, Anticancer and Anti-Hyperglycemic Assessments of Thiazolidine-2,4-Diones Bearing Sulfonylthiourea Moieties as Potent VEGFR-2 Inhibitors and PPARγ Agonists
Conjugated Dienones from Differently Substituted Cinnamaldehyde as Highly Potent Monoamine Oxidase?B Inhibitors: Synthesis, Biochemistry, and Computational Chemistry
DOI: https://doi.org/10.1021/acsomega.2c00397?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as
EGFR and COX-2 Dual Inhibitor: The Design, Synthesis, and Biological Evaluation of Novel Chalcones
Targeting tumor cells with pyrazolo[3,4-d] pyrimidine scaffold: A literature review on synthetic approaches, structure activity relationship, structural and target-based mechanisms
A pH-responsive, biocompatible, and non-toxic citric acid cross-linked polysaccharide-based hydrogel from Salvia spinosa L. offering zero-order drug release
Cancer Chemopreventive Potential and Chemical Profiling of Euphorbia abyssinica Endowed with Docking Studies
Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds
Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds
Isatin derivatives as broad-spectrum antiviral agents: the current landscape
Isatin derivatives as broad-spectrum antiviral agents: the current landscape
Development and Greenness Assessment of HPLC Method for Studying the Pharmacokinetics of Co-Administered Metformin and Papaya Extract
Development and Greenness Assessment of HPLC Method for Studying the Pharmacokinetics of Co-Administered Metformin and Papaya Extract
Article Solulan C24- and Bile Salts-Modified Niosomes for New Ciprofloxacin Mannich Base for Combatting Pseudomonas-Infected Corneal Ulcer in Rabbits
Solulan C24- and Bile Salts-Modified Niosomes for New Ciprofloxacin Mannich Base for Combatting Pseudomonas-Infected Corneal Ulcer in Rabbits
Nano-hydroxyapatite as a delivery system: overview and advancements
Nano-hydroxyapatite as a delivery system: overview and advancements
Synthesis of naringenin loaded lipid based nanocarriers and their in-vivo therapeutic potential in a rheumatoid arthritis model
Identifcation of non‑classical hCA XII inhibitors using combination of computational approaches for drug design and discovery
Evaluation of Ligustrazine-Based Synthetic Compounds for their Antiproliferative Effects
Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and Their Protein-Ligand Interactions
Synthesis of New 1-Aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone Oxime Ether Derivatives and Investigation of Their Cytotoxic Effects
Evaluation of ligustrazine based synthetic compounds for mechanism based antiproliferative effects
Molecular Detection of Fluoroquinolone Resistance among Multidrug-, Extensively Drug-, and Pan-Drug-Resistant Campylobacter Species in Egypt
Revealing the role of fluorine pharmacophore in chalcone scaffold for shifting the MAO-B selectivity: investigation of a detailed molecular dynamics and quantum chemical study
Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseases
Halogenated Coumarin?Chalcones as Multifunctional Monoamine Oxidase?B and Butyrylcholinesterase Inhibitors
DOI: https://doi.org/10.1021/acsomega.1c04252?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as
Halogenated Coumarin−Chalcones as Multifunctional Monoamine Oxidase‑B and Butyrylcholinesterase Inhibitors
DOI: https://doi.org/10.1021/acsomega.1c04252?urlappend=%3Fref%3DPDF&jav=VoR&rel=cite-as
Identification of Novel Potential VEGFR-2 Inhibitors Using a Combination of Computational Methods for Drug Discovery
Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors
Design, physico-chemical assessment and pharmacokinetics of a non-toxic orodispersible film for potential application in musculo-skeletal disorder
Design, Synthesis and Anticancer Profile of New 4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-amine-Linked Sulfonamide Derivatives with V600EBRAF Inhibitory Effect
Ameliorative effect of ethoxylated chalcone-based MAO-B inhibitor on behavioural predictors of haloperidol-induced Parkinsonism in mice: evidence of its antioxidative role against Parkinson?s diseases
Navigating into the Chemical Space of Monoamine Oxidase Inhibitors by Artificial Intelligence and Cheminformatics Approach
Strawberry and Ginger Silver Nanoparticles as Potential Inhibitors for SARS-CoV-2 Assisted by In Silico Modeling and Metabolic Profiling
Identification of non-classical hCA XII inhibitors using combination of computational approaches for drug design and discovery
Synthesis of N0 -(4-/3-/2-/Non-substituted benzylidene)- 4-[(4-methylphenyl)sulfonyloxy] Benzohydrazides and Evaluation of Their Inhibitory Activities against Monoamine Oxidases and β-Secretase
Synthesis of N′-(4-/3-/2-/Non-substituted benzylidene)-4-[(4-methylphenyl)sulfonyloxy] Benzohydrazides and Evaluation of Their Inhibitory Activities against Monoamine Oxidases and β-Secretase
Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders
Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights
Development of Halogenated Pyrazolines as Selective Monoamine Oxidase-B Inhibitors: Deciphering via Molecular Dynamics Approach
Development of 3-methyl/3-(morpholinomethyl) benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells
Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells
Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights
Heavy Metal Tolerance Trend in Extended-Spectrum β-Lactamase Encoding Strains Recovered from Food Samples
Antiulcer Potential of Olea europea L. cv. Arbequina Leaf Extract Supported by Metabolic Profiling and Molecular Docking
Potential Anticancer Lipoxygenase Inhibitors from the Red Sea-Derived Brown Algae Sargassum cinereum: An In-Silico-Supported In-Vitro Study
Cytotoxic Potential, Metabolic Profiling, and Liposomes of Coscinoderma sp. Crude Extract Supported by in silico Analysis
Simultaneous analysis of several antihypertensive drugs in different combinations: Application for determination of drug degradation products and process impurities
Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders
Identification of N-phenyl-2-(phenylsulfonyl)acetamides/ propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities
Identification of N-phenyl-2-(phenylsulfonyl)acetamides/propanamides as new SLC-0111 analogues: Synthesis and evaluation of the carbonic anhydrase inhibitory activities
New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation
Chromone Derivatives Bearing Pyridinium Moiety as Multi-Target-Directed Ligands against Alzheimer?s disease ?
Bioinspired imidazo[1,2-a:4,5-c?]dipyridines with dual antiproliferative and anti-migrative properties in human cancer cells: The SAR investigation
Design, synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors
Schiff Bases of Isatin and Adamantane-1-Carbohydrazide: Synthesis, Characterization and Anticonvulsant Activity
A study on the effectiveness of online teaching in pharmacy education from teacher and student perspective during the COVID-19 pandemic
Appraisal of the Antiarthritic Potential of Prazosin via Inhibition of Proinflammatory Cytokine TNF-?: A Key Player in Rheumatoid Arthritis
A New CDK2 Inhibitor with 3-Hydrazonoindolin-2-One Scaffold Endowed with Anti-Breast Cancer Activity: Design, Synthesis, Biological Evaluation, and In Silico Insights
Surface-modified polymeric nanoparticles for drug delivery to cancer cells
Analogues of 2′-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase
Design and synthesis of benzodiazepine?1,2,3?triazole hybrid derivatives as selective butyrylcholinesterase inhibitors
Evaluation of ligustrazine based synthetic compounds for mechanism based antiproliferative effects
Recent advances in nanotechnology-aided materials in combating microbial resistance and functioning as antibiotics substitutes
Potentially inappropriate medications use and its association with health-related quality of life among elderly cardiac patients
"Exploring the therapeutic potentials of highly selective oxygenated chalcone based MAO-B inhibitors in a haloperidol-induced murine model of Parkinson?s disease"
Madurella mycetomatis causing eumycetoma medical treatment: The challenges and prospects
3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies
MG132 inhibits the expression of PBX3 through miRNAs by targeting Argonaute2 in hepatoma cells
Revisiting the blood brain barrier: A hard nut to cracking the transportation of drug molecules
Development and Validation of UV-Spectrophotometric Method for the Determination of Atorvastatin Calcium Using Sodium Citrate as Hydrotropic Agent
Hydroxypropylcellulose-flurbiprofen conjugates: design, characterization, anti-inflammatory activity and enhanced bioavailability
Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights
Synthesis, biological evaluation and kinase profiling of novel S-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole derivatives as cytotoxic agents with apoptosis-inducing activity
Design, Synthesis, and In Vitro Cytotoxic Activity of Certain 2-[3-Phenyl-4-(pyrimidin-4-yl)-1H-pyrazol1-yl] acetamide Derivatives.
Design, Synthesis, and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety
Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool
Exploring the new horizons of drug repurposing: A vital tool for turning hard work into smart work
. Fe3O4 nanoparticles mediated synthesis of novel spirooxindole-dihydropyrimidinone molecules as Hsp90 inhibitor.