Publications
Development of PVDF@ZnO hybrid nanofibers with improved β-phase crystallinity and photocatalytic efficiency
Design and optimization of a universal, cost-effective gas sensing and photoconductivity measuring system
Decoding Multi-Omics Signatures in Lower-Grade Glioma Using Protein–Protein Interaction-Informed Graph Attention Networks and Ensemble Learning
Dual-Attention EfficientNet Hybrid U-Net for Segmentation of Rheumatoid Arthritis Hand X-Rays
Dual functional Zn-doped BaO microrods for photocatalysis and supercapacitor applications
Design, synthesis, and antibacterial efficacy of new methylene disalicylic acid/1,3,4-oxadiazole hybrids as dual inhibitors of DNA gyrase and topoisomerase IV
Design, synthesis, and antibacterial efficacy of new methylene disalicylic acid/1,3,4-oxadiazole hybrids as dual inhibitors of DNA gyrase and topoisomerase IV
Design and comprehensive characterization of a novel (3E)-3-{[(4-bromophenyl)amino]methylidene}-6-ethyl-2H-pyrano[3,2-c] quinoline-2,4,5(3H,6H)-trione (BPAMPQ) nanostructured for photosensor applications
DIVERSITY OF FIRST-LINE DEFENSE COMMITTEE FORMATION IN IMPROVING THE VALUE OF LONG COMMODITY COMPANIES
Diversity of first-line defense committee formation in improving the value of long commodity companies
Deep residual network enhanced with multilevel residual-of-residual for automatic classification of radio signals for 5G and beyond systems
DFT insights into RuC nanosheet as an adsorption platform for biogas molecules
Design a low-cost solar PV data logger and assess the application and accuracy with off-grid monocrystalline panels
DFT and experimental investigation of nanostructured boron subphthalocyanine chloride-films based hybrid photodiodes: Bridging organic and inorganic materials for sustainable light detection
DFT and Experimental Investigation of Nanostructured Boron Subphthalocyanine Chloride-films Based Hybrid Photodiodes: Bridging Organic and Inorganic Materials for Sustainable Light Detection
DFT insights into RuC nanosheet as an adsorption platform for biogas molecule
Different orthotics in management of plantar fasciitis: a systematic review
Decoding the Structure–Property Paradigm in LiX5Sb11 (X= Fe, Mn) Skutterudites: A Synergistic Computational–Experimental Exploration
Decoding the Structure–Property Paradigm in LiX5Sb11(X = Fe, Mn) Skutterudites: A Synergistic Computational–Experimental Exploration For Energy Storage System Applications
Development of Green-Assessed and Highly Sensitive Spectrophotometric Methods for Ultra-Low-Level Nitrite Determination Using Rhodanine and 7-Hydroxycoumarin in Environmental Samples
Development of Green-Assessed and Highly Sensitive Spectrophotometric Methods for Ultra-Low-Level Nitrite Determination Using Rhodanine and 7-Hydroxycoumarin in Environmental Samples
Development of Green-Assessed and Highly Sensitive Spectrophotometric Methods for Ultra-Low-Level Nitrite Determination Using Rhodanine and 7-Hydroxycoumarin in Environmental Samples
Development of Green-Assessed and Highly Sensitive Spectrophotometric Methods for Ultra-Low-Level Nitrite Determination Using Rhodanine and 7-Hydroxycoumarin in Environmental Samples
Development of green-assessed and highly sensitive spectrophotometric methods for ultra-low-level nitrite determination using rhodanine and 7-hydroxycoumarin in environmental samples
Development of ganciclovir/resveratrol coloaded bilosomes for improvement of ophthalmic delivery and therapeutic efficacy
Dynamics and Chaos Analysis of the Fractional-Order Lü System Using a Hybrid Approach
Development of ganciclovir/resveratrol coloaded bilosomes for improvement of ophthalmic delivery and therapeutic efficacy
Development of ganciclovir/resveratrol coloaded bilosomes for improvement of ophthalmic delivery and therapeutic efficacy
Determinants of Menstrual Hygiene Practices Among Adolescent Schoolgirls in Saudi Arabia: Implications for Adolescent Health Promotion
Determinants of energy consumption in selected ASEAN countries: New evidence from panel ARDL and wavelet coherence approaches
Development of ganciclovir/resveratrol coloaded bilosomes for improvement of ophthalmic delivery and therapeutic efficacy
Design, synthesis, in silico studies, and antiproliferative activity of a novel series of thiazole/1,2,3-triazole hybrids as apoptosis inducers and multi-kinase inhibitors endowed with anti-breast cancer activity
Development of feasible solid dispersion for improvement of biopharmaceutical properties of polyphenols: in vitro and in vivo studies
Direct seawater electrolysis using interconnected-feather structured CoOx@Co: Anodization-derived cobalt alloys with tunable nanoscale morphology
Designing architecture and performance evaluation of solar cells with MAPbI3 and Cs2 CuSbCl6 perovskites as active layers
Development and enhancement of metamaterial-inspired Ag-GaAs THz MIMO antenna with optimized diversity metrics using data-driven machine learning algorithms for future 6G networks
Deciphering the Skin Anti-Aging and Hair Growth Promoting Mechanisms of Opophytum forskahlii Seed Oil via Network Pharmacology
Determinants of loneliness and quality of life among rural community-dwelling older adults in Egypt: A cross-sectional descriptive study
Design of LaFeO₃/CuBi₂O₄ composite for enhanced visible-light photocatalytic degradation of atrazine: Insights into activity, stability, and mechanism
Dual-Attention EfficientNet Hybrid U-Net for Segmentation of Rheumatoid Arthritis Hand X-Rays
Decoding Multi-Omics Signatures in Lower-Grade Glioma Using Protein–Protein Interaction-Informed Graph Attention Networks and Ensemble Learning
Does the Health Kuznets Curve hypothesis hold for Saudi Arabia? A quantile ARDL analysis of disability-adjusted life years and their burden components
DREM-based predefined-time adaptive learning control for nonlinear systems with actuator faults and input delay
Deriving Hermite–Hadamard-Type Inequalities via Stochastic k-Caputo Fractional Derivatives
Deep Learning-Based Multiclass Attacks Detection and Classification in Automatic Generation Control
Development of feasible solid dispersion for improvement of biopharmaceutical properties of polyphenols: in vitro and in vivo studies
Does it pay to invest in environmental sustainability? Green innovation and costs of production
Do Changes In Mental And Physical Energy And Fatigue Impact Changes On Neck Muscle Coordination?
Density-Based Recovery Followed by Regeneration of Anode Graphite From Spent Lithium-Ion Batteries Containing Mixed Battery Types
Density‐Based Recovery Followed by Regeneration of Anode Graphite From Spent Lithium‐Ion Batteries Containing Mixed Battery Types
Discovering periodontitis biomarkers and therapeutic targets through bioinformatics and ensemble learning analysis.
Decoding salt-adaptive peduncle length in barley through genome-wide association and candidate gene validation.
Development of poly (lactic-Co-glycolic acid) nanoparticles of retinol using supercritical fluid technology: Factorial design-based optimization, physicochemical characterization and cell viability assessment
Development of carboximidamide small molecule nanogels as potent antimicrobial functional drug delivery systems
Dynamic Response of Saturated Soil to Anisotropic Thermal Conductivity Impacts Under the Moore‒Gibson‒Thompson Thermoelastic Mode
Dynamic Response of Saturated Soil to Anisotropic Thermal Conductivity Impacts Under the Moore‒Gibson‒Thompson Thermoelastic Model
Dynamic Response of Saturated Soil to Anisotropic Thermal Conductivity Impacts Under the Moore‒Gibson‒Thompson Thermoelastic Model
Dynamic Response of Saturated Soil to Anisotropic Thermal Conductivity Impacts Under the Moore‒Gibson‒Thompson Thermoelastic Model
Development and Optimization of Setraconazole Invasomes, Gels, and Films for Enhanced Transdermal Delivery and Topical Fungal Treatment
DownLink amplified loss function module for 5G air to terrestrial communication networks
Decentralized Identity Management in Cloud Computing: A Blockchain‐Based Solution With Automatic Provisioning Techniques
Design and Analysis of C-Band Tunable On-Chip Integrated CW-MOPA Based on Er–Yb:Co-Doped Waveguides in Lithium Niobate on Insulator Platform
Detection of DICER1 Mutation at an Early Stage Using UniCNN Model
Deep Learning Applications in Dental Image-Based Diagnostics: A Systematic Review
Dialdehyde Chitosan/Semicarbazide Synthesis for Lanthanum, Cerium, and Neodymium Ions Recovery from Phosphate Leachate
Developing a multidimensional sustainable framework for measuring inclusive Growth: Evidence from Egypt
Decentralized Identity Management in Cloud Computing: A Blockchain-Based Solution With Automatic Provisioning Techniques
Dynamic behavior of a hollow cylinder under spatial–temporal nonlocality and fractional thermoelasticity incorporating the two-parameter Mittag–Leffler kernel
Dynamics of a viscoelastic microbeam on Winkler foundation induced by laser excitation: A nonlocal MGT heat conduction approach
Defected ground structure antenna array with metasurface inspired interlinked CSRR for 5G millimeter wave applications
Developing thermally stable strontianite/polymer bio-nanocomposites with enhanced optical and electric properties for optoelectronics and energy storage applications
Design of a Novel CMOS Transimpedance Amplifier Based on a Current Mirror
Design, antiproliferative potency, and in silico studies of novel 5-methylfuran-3-yl)thio)-3- phenylquinazolin-4(3H)-one based derivatives as potential EGFR inhibitors
Demographic Parameters and Life History Traits of Neoseiulus cucumeris (Oudemans) (Acari: Phytoseiidae) Influenced by Different Temperatures and Two Types of Food
Deep learning for enhancing automatic classification of M-PSK and M-QAM waveform signals dedicated to single-relay cooperative MIMO 5G systems
Deep learning for enhancing automatic classification of M-PSK and M-QAM waveform signals dedicated to single-relay cooperative MIMO 5G systems
Development and Optimization of Setraconazole Invasomes, Gels, and Films for Enhanced Transdermal Delivery and Topical Fungal Treatment
Design, synthesis, antitumor activities, molecular docking and ADMET of new benzochromenes, benzochromenopyrimidines and benzochromeno-triazolopyrimidines
Dynamics of urinary tract infections: a comprehensive study on antimicrobial susceptibility, virulence profiling and molecular epidemiology of uropathogenic Escherichia coli from Pakistan
Defect-driven innovations in photocatalysts: Pathways to enhanced photocatalytic applications
Development of Sesamol Loaded-Polymer-Lipid Blend Nanoparticles: Statistical Optimization, In- Vitro, and Preclinical Assessment
Development of Sesamol Loaded-Polymer-Lipid blend nanoparticles: Statistical optimization, in-vitro, and preclinical assessment
Dysmenorrhea-Demographics, Absenteeism, Management and Healthcare Seeking Behavior, A Cross-Sectional Study Done in Saudi Arabia
Deep Learning Applications in Dental Image-Based Diagnostics: A Systematic Review
Determinants of Oral Delivery from Two Lipid Nanocarriers: Systematic Review and Meta-analysis of Bioavailability Studies.
Designing a Precision Epitope-Based Vaccine Against Paragonimus westermani Using Immunoinformatics, Biophysical Analysis, and Molecular Modeling Approaches
Discovery of antitubercular potential of trans-3-indoleacrylic acid and its derivatives targeting Mycobacterium tuberculosis: A combined in vitro and in silico investigation
Development of oxidized sodium alginate/silica hybrid as efficient adsorbent for anionic and cationic dyes: mechanism and thermodynamic studies
Design and evaluation of carnosic acid-loaded thermosensitive lipidic nanogels for nasal delivery: ex vivo permeation, nasal ciliotoxicity, and antioxidant assessment
Design, synthesis, and biological investigation of new thiazole-based derivatives as multi-targeted inhibitors endowed with antiproliferative, antioxidant, and antibacterial properties
Development of WO3: PVP: PEG hybrid nanocomposite thin films for optoelectronics applications: Structural, optical, and photoelectrical properties investigations
Decentralized multi-agent federated and reinforcement learning for smart water management and disaster response
Development of a novel electrochemical sensor modified with graphene oxide/multi-walled carbon nanotubes composite for the analysis of acetaminophen and tramadol in different matrices
Development of a novel electrochemical sensor modified with graphene oxide/multi‑walled carbon nanotubes composite for the analysis of acetaminophen and tramadol in different matrices
Development of Luteolin-Loaded Calcium Alginate and Gum Tragacanth Blend Microbeads for Oral Delivery: In Vitro Characterization, Antioxidant, Antimicrobial, and Anticancer Activity Against Colon Cancer Cell Line (HT-29)
Development of etoricoxib-loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: optimization, ex vivo permeation, histopathology, and in vivo anti-inflammatory study
Decentralized multi-agent federated and reinforcement learning for smart water management and disaster response
Design, characterization, antioxidant activity, and molecular docking study of sulfadiazine derivative-based Ni (II) and Cu (II) complexes
Design, characterization, antioxidant activity, and molecular docking study of sulfadiazine derivative-based Ni (II) and Cu (II) complexes
Development of a novel electrochemical sensor modified with graphene oxide/multi‑walled carbon nanotubes composite for the analysis of acetaminophen and tramadol in different matrices
Discovery of 1-phenyl-1,2,3-triazole ureas as dual VEGFR-2/JNK-1 type II kinase inhibitors targeting pancreatic cancer
Drug Repositioning as a Promising Approach for the Eradication of Emerging and Re-emerging Viral Agents
Detection and Diagnosis of ECH Signal Wearable System for Sportsperson using Improved Monkey-based Search Support Vector Machine
Development and characterization of sustainable chitosan film enriched with ashwagandha extract as an alternative packaging material for enhancing shelf life of fresh-cut fruits
Detection and quantification of some ethanol-producing bacterial strains in the gut of mouse model of non-alcoholic fatty liver disease: Role of metformin
Development of Lipid Polymer Hybrid Nanoparticles of Abietic Acid: Optimization, In-Vitro and Preclinical Evaluation
Development of atomoxetine-loaded NLC in situ gel for nose-to-brain delivery: Optimization, in vitro, and preclinical evaluation
Deep reinforcement learning based control of a grid connected inverter with LCL-filter for renewable solar applications
Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies
Digital intervention for tokophobia: a randomized controlled trial of internet-based cognitive behavioral therapy on fear of childbirth and self-efficacy among Egyptian pregnant women
Development of high-performance polysulfone ultrafiltration membranes with enhanced permeability and antifouling properties via amino-functionalized TiO₂ nanotube incorporation
Decrypting the Possible Mechanistic Role of Fenofibrate in Alzheimer's Disease and Type 2 Diabetes: The Truth and Mystery
Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies
Development of high-performance polysulfone ultrafiltration membranes with enhanced permeability and antifouling properties via amino-functionalized TiO2 nanotube incorporation
Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies
Distinct Circulating Biomarker Profiles Associated with Type 2 Diabetes in a Regional Cohort-A Cross-Sectional Study
Design, Characterization, Antimicrobial Activity, and In Silico Studies of Theinothiazoloquinazoline Derivatives Bearing Thiazinone, Tetrazole, and Triazole Moieties
Detection of a Spatial Source Term Within a Multi-Dimensional, Multi-Term Time-Space Fractional Diffusion Equation
Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study
Design, characterization, antioxidant activity, and molecular docking study of sulfadiazine derivative-based Ni (II) and Cu (II) complexes
Design, synthesis, antimalarial activity, and in-silico studies of new benzimidazole/pyridine hybrids as dihydrofolate reductase inhibitors
Depression unveiled: Insights into etiology and animal models for behavioral assessment, exploring the multifactorial nature and treatment of depression
Development of a Sustainable and Optimized Energy Ecosystem with Real-Time Monitoring through Innovative IoT-Based Actuator Design for Human-Centric Security in Smart Cities
Dynamics of chemical reactive on magneto Hybrid Nanomaterial with heat radiation due to porous exponential plate: Laplace transform technique for the heat and mass
Developing innovative PVA@TiO2-based adsorbents for CO2 capture via multiple metal oxide dopants for sustainable development
Developing innovative PVA@TiO2-based adsorbents for CO2 capture via multiple metal oxide dopants for sustainable development
Does Sequential Thoracoscopic Sympathectomy Affect the Development of Postoperative Compensatory Sweating in Children?.
Design, Characterization, and DFT exploration of new mononuclear Fe(III) and Co(II) complexes based on Isatin-hydrazone derivative: Anti-inflammatory profiling and molecular docking insights
Deciphering farnesol’s anti-arthritic and immunomodulatory potential by targeting multiple pathways: a combination of network pharmacology guided exploration and experimental verification
Decorin alleviates non-alcoholic fatty liver disease in rats with polycystic ovary syndrome
Design, Characterization, and DFT exploration of new mononuclear Fe(III) and Co(II) complexes based on Isatin-hydrazone derivative: Anti-inflammatory profiling and molecular docking insights
Developing a multidimensional sustainable framework for measuring inclusive Growth: Evidence from Egypt
Direct synthesis and catalytic activity of oxazole derivative copper II complex encapsulated in zeolite from rice husk
Direct synthesis and catalytic activity of oxazole derivative copper II complex encapsulated in zeolite from rice husk
Dual Repurposing of End-of-Life BWRO Membranes: Ultrafiltration Membranes for Advanced Wastewater Treatment and Cation Exchange Membranes for Fungal Microbial Fuel Cells
Design and development of hexagonal-shaped copper and liquid metamaterial-loaded superstrate patch antenna for 5G, WLAN, tracking and detection applications
Dual Repurposing of End-of-Life BWRO Membranes: Ultrafiltration Membranes for Advanced Wastewater Treatment and Cation Exchange Membranes for Fungal Microbial Fuel Cells
Detection of Heavy Metals Present in the Environment by Biosensor
Demographic factors, knowledge, attitude and perception and their association with nursing students’ intention to use artificial intelligence (AI): a multicentre survey across 10 Arab countries
Design and synthesis of a novel isoleucine-derived Schiff base ligand: Structural characterization, molecular docking, and in vitro biological activity evaluation
Does effectiveness of internal corporate governance and top management influence corporate performance? The role of ownership concentration
Detection of diversity of fetal heart function in pregnancy-induced hypertension patients by ultrasonography in Aljouf Region, Saudi Arabia
Detecting respiratory diseases using machine learning-based pattern recognition on spirometry data
Dynamic proactive–reactive scheduling for URLLC in 5G: Leveraging XGBoost and network virtualization
Design and Optimization of Graphene‑Based Ultra‑Wideband Surface Plasmon Resonance Solar Absorber Using Machine Learning
Deep learning and ubiquitous systems for disabled people detection using YOLO models
Design and Investigation of Surface Plasmon Resonance Solar Absorber Based on Graphene for Renewable Energy Applications
Direct synthesis and catalytic activity of oxazole derivative copper II complex encapsulated in zeolite from rice husk
Development and characterization of sodium alginate beads incorporating functionalized poly(acrylonitrile-co-styrene)/ carbon nanotubes for effective Fe(II) ion adsorption from aqueous solutions
Development and characterization of sodium alginate beads incorporating functionalized poly(acrylonitrile-co-styrene)/ carbon nanotubes for effective Fe(II) ion adsorption from aqueous solutions
Design, Synthesis, Pharmacological Evaluation of Quinazolin-4(3H)-Ones Bearing Urea Functionality as Potential VEGFR-2 Inhibitors
Design, Synthesis, Pharmacological Evaluation of Quinazolin-4(3H)-Ones Bearing Urea Functionality as Potential VEGFR-2 Inhibitors
Discussion on optical solitons, sensitivity and qualitative analysis to a fractional model of ion sound and Langmuir waves with Atangana Baleanu derivatives
Degradative potential of laccase and manganese peroxidase to mycotoxins on infected maize grains by fungi with docking interaction studies
Design and synthesis of new quinoline-ester/-amide derivatives as potent antiproliferative agent targeting EGFR and BRAFV600E kinases
DSTC-Sum: A Supervised Video Summarization Model Using Depthwise Separable Temporal Convolutional
Data on selfـــefficacy and its sources during the COVID-19 crisis: A Saudi auditor’s perspective
Does Managerial Power Explain the Association between Agency Costs and Firm Value? The French Case
Design and Synthesis of Novel 2-(2-(4-bromophenyl)quinolin-4-yl)-1,3,4-oxadiazole Derivatives as Anticancer and Antimicrobial candidates: In vitro and In silico studies
Dynamics of nonlocal correlation of two superconducting charge qubits induced by intrinsic decoherence
Dynamics of nonlocal correlation of two superconducting charge qubits induced by intrinsic decoherence
Does effectiveness of internal corporate governance and top management influence corporate performance? The role of ownership concentration
Design, synthesis, biological evaluation, kinetic studies and molecular modeling of imidazo-isoxazole derivatives targeting both α-amylase and α-glucosidase inhibitors
Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action
Development of Antimicrobial and Insecticidal Silk Fabrics via Eco-printing with Natural Dyes from Agricultural Wastes
Dielectric relaxation investigations of polyester/CoFe2O4 composites
Design, Antimicrobial Testing, and Molecular Docking Studies of New Chalcone and Pyrimidine Derivatives based on 2-phenyl-1H-pyrazol-3(2H)-one
Discerning of isatin-based monoamine oxidase (MAO) inhibitors for neurodegenerative disorders by exploiting 2D, 3D-QSAR modelling and molecular dynamics simulation
Direct Current Control of Grid Connected Two Level Inverter With LCL-Filter Using Deep Reinforcement Learning Algorithm
Dynamic Extraction Time’s Effect on Phytochemical Characterization of Vitex agnus-castus Dry Biomass with Healing Properties and their Activity Against Microorganisms and Ovarian Cancer
Design systematic wireless inventory trackers with prolonged lifetime and low energy consumption in future 6G network
Development of Antimicrobial and Insecticidal Silk Fabrics via Eco-printing with Natural Dyes from Agricultural Wastes
Development of Lipid Polymer Hybrid Nanoparticles of Abietic Acid: Optimization, In-Vitro and Preclinical Evaluation
Design and Simulation of Thermoelectric Generator to Recover Waste Heat of Chimney
Does financial reporting quality matter for the auditee characteristics-audit fees relationship? Evidence from an emerging market
Deciphering temporal perspectives: A key to happiness and optimism for healthy aging in nursing practices”
Developing the teledentistry acceptance survey for dentists – TAS-D: a Delphi study.
Decision on "Graphene-based Multilayer Surface Plasmon Resonance Solar absorber in the UV to MIR Region for Renewable Energy Application
Design and Development of Surface Plasmon Resonance‑Based Solar Thermal Absorber Using Fe‑Ti‑SnSe2 Multilayered Approach for Thermal Heating Application
Development of an RP-HPLC Method for Quantifying Diclofenac Diethylamine, Methyl Salicylate, and Capsaicin in Pharmaceutical Formulation and Skin Samples
Development of an RP-HPLC Method for Quantifying Diclofenac Diethylamine, Methyl Salicylate, and Capsaicin in Pharmaceutical Formulation and Skin Samples
Development of an RP-HPLC Method for Quantifying Diclofenac Diethylamine, Methyl Salicylate, and Capsaicin in Pharmaceutical Formulation and Skin Samples
Development of an RP-HPLC Method for Quantifying Diclofenac Diethylamine, Methyl Salicylate, and Capsaicin in Pharmaceutical Formulation and Skin Samples
Development of an RP-HPLC Method for Quantifying Diclofenac Diethylamine, Methyl Salicylate, and Capsaicin in Pharmaceutical Formulation and Skin Samples
Does Debt Structure Explain the Relationship between Agency Cost of Free Cash Flow and Dividend Payment? Evidence from Saudi Arabia
Digital Dilemma of Cyberbullying Victimization among High School Students: Prevalence, Risk Factors, and Associations with Stress and Mental Well-Being
Digital Dilemma of Cyberbullying Victimization Among High School Students: Prevalence, Risk Factors, and Associations with Stress and Mental Well-being.
Determining the Association Between MSP1/2 Variant and Multiplicity of Infection on Incidence of Severe Malaria in Sudanese Children in Gezira State, Sudan
Divine resilience: Unveiling the impact of religious coping mechanisms on pain endurance in arab older adults battling chronic pain
Deformation in a micropolar material under the influence of Hall current and initial stress fields in the context of a double-temperature thermoelastic theory involving phase lag and higher orders
Data-driven Strategy for Evaluating the Response of Eco-Friendly Concrete at Elevated Temperatures for Fire Resistance Construction
Design and Synthesis of Novel N-Benzylidene Derivatives of 3-Amino-4-imino-3,5-dihydro-4H-chromeno[2,3-d]pyrimidine under Microwave, In Silico ADME Predictions, In Vitro Antitumoral Activities and In Vivo Toxicity
Development, optimization and characterization of cisplatin loaded cubosomes for human lung carcinoma
Detecting Psychological Interventions Using Bilateral Electromyographic Wearable Sensors
Doping and precoating by Cu-metal and annealing impacts on some physical properties and applications of MnS thin films
Dynamical Behavior and Expressions of Solutions of a Class of Higher-Order Nonlinear Difference Equations
Design and performance evaluation of a novel metamaterial broadband THz filter for 6G applications
Designing Thieno[3,4-c]pyrrole-4,6-dione Core-Based, A2–D–A1–D–A2-Type Acceptor Molecules for Promising Photovoltaic Parameters in Organic Photovoltaic Cells
Data Analysis of Coronavirus CoVID-19: Study of Spread and Vaccination in European Countries
Development of a Pseudo-typed Virus Particle Based Method to Determine the Efficacy of Virucidal Agents.
Diagnosing osteoporosis using deep neural networkassisted optical image processing method.
Driving the future: Leveraging digital transformation for sustainable transportation
Does globalization matter for environmental sustainability? New evidence from the QARDL approach
Design of a 3-bit 2.2 ps step 357.5 ps range 0.247 μm2 0.85 μW 45 nm All-MOS delay element
Design, Antimicrobial Testing, and Molecular Docking Studies of New Chalcone and Pyrimidine Derivatives Based on 2-phenyl-1H-pyrazol 3(2H)-one
Development of piperine-loaded soft binary ethosomal gel to improve transdermal delivery: Box-Bhekhen design optimization, ex-vivo permeation, and antimicrobial evaluation
Do Received Remittances Cause Dutch Disease in Developed and Developing Countries
Determining the effect of hypertension and diabetes following stroke in tertiary hospital, Aljouf, Saudi Arabia.
Design and construction of novel pyridinepyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies
Deep insights into the Cu- and W-doped Na0.5Bi0.5TiO3 solid solution: A study focusing on optical, dielectric and electrical properties
Discovery of Potent Indolyl-Hydrazones as Kinase Inhibitors for Breast Cancer: Synthesis, X-ray Single-Crystal Analysis, and In Vitro and In Vivo Anti-Cancer Activity Evaluation
Design, synthesis, and biological evaluation of indole-2-carboxamides as SARS CoV-2 main protease inhibitors
Design, synthesis, characterization, spectral, chemical analysis, biological evaluation, and molecular docking studies of novel fatty Schiff base ligands and their nickel and mercury complexes
Digital Health Interventions for Promoting Healthy Aging: A Systematic Review of Adoption Patterns, Efficacy, and User Experience
Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents
Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies
Dynamical and physical characteristics of soliton solutions to the (2+1)-dimensional Konopelchenko-Dubrovsky system
Development of Soft Luliconazole Invasomes Gel for Effective Transdermal Delivery: Optimization to In-Vivo Antifungal Activity
Design and Performance Evaluation of a Novel Metamaterial Broadband THz Filter for 6G Applications
Diagnosis of patellofemoral osteoarthritis using enhanced sequential deep learning techniques
Design and performance evaluation of a novel metamaterial broadband THz filter for 6G applications
Design and performance evaluation of a novel metamaterial broadband THz filter for 6G applications
Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction
Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction
Developing Physical Therapy Students’ Medical Report Writing Skills During COVID-19: A TPACK Based ESP Course.
Dynamics of two-qubit Heisenberg XY state: external magnetic field and intrinsic decoherence effects
Development of Artificial Intelligence Based Safety Performance Measures for Urban Roundabouts
Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction
Discovery of new 5-substituted-indole-2- carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action
Design of biosensor for synchronized identification of diabetes using deep learning
Design, synthesis, and biological evaluation of indole-2-carboxamides as SARS CoV-2 main protease inhibitors
Design, synthesis, and biological evaluation of indole-2-carboxamides as SARS CoV-2 main protease inhibitors
Design, Synthesis, and Biological Evaluation of New Indole-2-Carboxamides as Anti-Coronaviral Agents Targeting SARS CoV-2 Main Protease inhibitors
Deep learning-enhanced diabetic retinopathy image classification
Design, synthesis, docking and mechanistic studies of new thiazolyl/thiazolidinylpyrimidine-2,4-dione antiproliferative agents
Data Protection in IoT using CoAP based on Enhanced DTLS
Diagnosis of patellofemoral osteoarthritis using enhanced sequential deep learning techniques
Direct synthesis of sodium doped Cu2O/GO nanocomposites for catalytic hydrogen production from NaBH4
Discovery of Novel Tetramethylpyrazine Containing Chalcone Derivatives as Anti-Inflammatory Agents
Designing a Graphene Metasurface Organic Material Sensor for Detection of Organic Compounds in Wastewater
Designing of Graphene Meta-surface Organic Material Sensor for Detection of Organic Compounds in Wastewater (Sh)
Design, synthesis and antimicrobial activity of novel quinoline- 2-one hybrids as promising DNA gyrase and topoisomerase IV inhibitors
Dosimetric characterization of CyberKnife® robotic SRS using MOSFET-based "MOskin" detector
Does Financial Development Really Improve Environmental Quality in Al-Jouf Region? Empirical Contribution to the Environmental Politics
Development of Olive Oil Containing Phytosomal Nanocomplex for Improving Skin Delivery of Quercetin: Formulation Design Optimization, In Vitro and Ex Vivo Appraisals
Distinctive spectroscopic features of samarium ions in the lithium zinc-borate glass
Deep learning models for multilabel ECG abnormalities classification: A comparative study using TPE optimization
Direct synthesis of sodium doped Cu2O/GO nanocomposites for catalytic hydrogen production from NaBH4
Dynamo script and a BIM-based process for measuring embodied carbon in buildings during the design phase
Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action
Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAFV600E
Design, synthesis, docking and mechanistic studies of new thiazolyl/thiazolidinylpyrimidine-2,4-dione antiproliferative agents
Development of Olive Oil Containing Phytosomal Nanocomplex for Improving Skin Delivery of Quercetin: Formulation Design Optimization, In Vitro and Ex Vivo Appraisals
Discovery of new 5-substituted-indole-2- carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action
Detection and Selective Removal Strategy of Thorium Ions Using a Novel Fluorescent Ligand and Hybrid Mesoporous γ-Al2O3-like Nanoneedles
Development of Bi2O3/MoSe2 mixed nanostructures for photocatalytic degradation of methylene blue dye
Diagnosing Melanomas in Dermoscopy Images Using Deep Learning
Development of a Smart Signalization for Emergency Vehicles
Design and construction of novel pyridine-pyrimidine hybrids as selective COX-2 suppressors: anti-inflammatory potential, ulcerogenic profile, molecular modeling and ADME/Tox studies Mohamed E. Shaker,Hesham A. M. Goma,Izzeddin Alsalahat,Nadia A. A. Elkanzi,Amany A. Azouz,Mohamed Sadek Abdel-Bakky, show all Pages 1804-1817 | Received 10 May 2023, Accepted 27 Nov 2023, Published online: 28 Dec 2023 Cite this article https://doi.org/10.1080/07391102.2023.2293257 CrossMark LogoCrossMark Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days Full Article Figures & data References Supplemental Citations Metrics Reprints & Permissions Read this article Abstract NSAIDs represent a mainstay in pain and inflammation suppression, and their actions are mainly based on inhibiting COX-1 and COX-2 enzymes. Due to the adverse effects of these drugs, especially on the stomach and heart, scientists efforts have been directed to manufacture selective COX-2 without cardiovascular side effects and with minimal effects on the stomach. The cardiovascular side effects are thought to be related to the chemical composition rather than mechanism of action of these drugs. Novel pyridopyrimidines, 9a-j, were prepared and their chemical structures were confirmed by NMR, mass and IR Spectra, and elemental analysis. The effect of the 9a-j compounds on COX-1 and COX-2 was assessed and it was found that 2-hydrazino-5-(4-methoxyphenyl)-7-phenyl-3H-pyrido[2,3-d)pyrimidin-4-one (9d) was the most potent COX-2 inhibitor (IC50 = 0.54 uM) compared to celecoxib (IC50 = 1.11 uM) with selectivity indices of 6.56 and 5.12, respectively. The in vivo inhibition of paw edema of novel compounds 9a-j was measured using carrageenan-induced paw edema method, and that 2-hydrazino-5-(4-methoxyphenyl)-7-phenyl-3H-pyrido[2,3-d)pyrimidin-4-one (9d) showed the best inhibitory activity in comparison with the other compounds and celecoxib. The gastroprotective effect of the potent derivatives 9d, 9e, 9f, 9 g and 9h was investigated. 2-Hydrazino-5-(4-methoxyphenyl)-7-phenyl-3H-pyrido[2,3-d)pyrimidin-4-one (9d) and 7-(chlorophenyl)-hydrazino-5-(4-methoxyphenyl)-3H-pyrido[2,3-d)pyrimidin-4-one (9e) showed ulcer indices comparable to celecoxib (1 and 0.5 vs 0.5, respectively). Docking studies were carried out and they confirmed the mechanistic action of the designed compounds Keywords: COXs inhibitorsanti-inflammatorycelecoxibNSAIDspyridopyrimidines Disclosure statement No potential conflict of interest was reported by the author(s). Additional information Funding This research was funded by the Deanship of Scientific Research at Jouf University, Saudi Arabia through a research grant group to ME Shaker (DSR-2022-RG-0149). Share Related research People also read Recommended articles Cited by 5 Information for Authors R&D professionals Editors Librarians Societies Open access Overview Open journals Open Select Dove Medical Press F1000Research Opportunities Reprints and e-prints Advertising solutions Accelerated publication Corporate access solutions Help and information Help and contact Newsroom All journals Books Keep up to date Register to receive personalised research and resources by email Sign me up Taylor and Francis Group Facebook pageTaylor and Francis Group X Twitter pageTaylor and Francis Group Linkedin page Taylor and Francis Group Youtube pageTaylor and Francis Group Weibo page Copyright © 2025Informa UK Limited Privacy policy Cookies Terms & conditions Accessibility Registered in England & Wales No. 01072954 5 Howick Place | London | SW1P 1WG Taylor and Francis Group PDF Help
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Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors
Design and Evaluation of Antimicrobial Activity of New Pyrazole, 1,2,4-Triazole, and 1,3,4-Thiadiazol Derivatives Bearing 1,4-Dihydroquinoxaline Moiety
Determination of Serum Adiponectin Levels in Type 2 Diabetes Patients of the Saudi Population in the Al-Jouf Region
Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors
Determination of Serum Adiponectin Levels in Type 2 Diabetes Patients of the Saudi Population in the Al-Jouf Region
Design, Sonosynthesis, Quantum-Chemical Calculations, and Evaluation of New Mono- and Bis-pyridine Dicarbonitriles as Antiproliferative Agents
Design of a miniaturized dipole RFID tag antenna
Development and Validation of UV-Spectrophotometric Method for the Determination of Atorvastatin Calcium Using Sodium Citrate as Hydrotropic Agent
Does IFRS Adoption Effect on the Cost of Capital Differ Among Firms?
Dark Tried Around the World : Darkness around the world and in the sexes in 49 countries: ) Country-level correlates of the Dark Triad traits
DevelopmentandcharacterizationofTlGaSe2thinfilm-basedphotodetectorfor visible-lightphotodetectorapplications
Design of a Smart Medical Bracelet Prototype for COVID-19 based on Wireless Sensor Networks
Design, fabrication and optical characterizations of pyrimidine fused quinolone carboxylate moiety for photodiode applications
Development of activated carbon-impregnated alginate*-cyclodextrin/gelatin beads for highly performance sorption of 2,4-dichlorophenol from wastewater
Development of activated carbon-impregnated alginate*β-cyclodextrin/gelatin beads for highly performance sorption of 2,4-dichlorophenol from wastewater
Design, Synthesis, and In Vitro Cytotoxic Activity of Certain 2-[3-Phenyl-4-(pyrimidin-4-yl)-1H-pyrazol1-yl] acetamide Derivatives.
Daily versus stat vitamin D supplementation during pregnancy; A prospective cohort study
Daily versus stat vitamin D supplementation during pregnancy; A prospective cohort study
Development of solid lipid nanoparticle as carrier of pioglitazone for amplification of oral efficacy: Formulation design optimization, in-vitro characterization and in-vivo biological evaluation
Development of solid lipid nanoparticle as carrier of pioglitazone for amplification of oral efficacy: Formulation design optimization, in-vitro characterization and in-vivo biological evaluation
Development of biocompatible tri-layered nanofibers patches with endothelial cells for cardiac tissue engineering
Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application
Developing Cloud Computing Time Slot-availability Predictions Using an Artificial Neural Network
Design, Synthesis, and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety
Determination of bacterial profile and spectrum of antimicrobial drug resistance in pediatric wound infections
Design and Implementation of Secured E-Business Structure with LTL Patterns for User Behavior Prediction
Development of novel dapagliflozin loaded solid self-nanoemulsifying oral delivery system: Physiochemical characterization and in vivo antidiabetic activity
Dipeptidyl peptidase-4 inhibitors can inhibit angiotensin converting enzyme
Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers
Detection efficiency of NaI(Tl) detector based on the fabricated calibration of HPGe detector
Development of novel dapagliflozin loaded solid self-nanoemulsifying oral delivery system: Physiochemical characterization and in vivo antidiabetic activity
Development of novel dapagliflozin loaded solid self-nanoemulsifying oral delivery system: Physiochemical characterization and in vivo antidiabetic activity
Differential Game for Distributed Power Control in Device-to-Device Communications Underlaying Cellular Networks
Dielectric relaxation behavior of three-phase MWCNTs-PANI polystyrene nanocomposites
Document/query expansion based on selecting significant concepts for context based retrieval of medical images
Diarylpyrrolone based fluorophore for the selective spectrofluorometric method for determination of Linagliptin antidiabetic drug in pharmaceutical tablets
Data sharing using proxy re-encryption based on DNA computing
Deep eutectic solvent for an expeditious sono-synthesis of novel series of bis-quinazolin-4-one derivatives as potential anti-cancer agents
DETERMINATION OF HEMATOLOGICAL PARAMETERS AND D-DIMER AMONG SUDANESE CHILDREN INFECTED WITH PLASMODIUM FALCIPARUM IN KHARTOUM STATE – SUDAN.
Dynamics of the entanglement and teleportation of thermal state of a spin chain with multiple interactions
Dynamic Multiple Junction Selection Based Routing Protocol for VANETs in City Environment
Does management entrenchment explain agency costs of equity: Evidence from French firms
Discontinuous Galerkin method coupled with an integral representation for solving the three-dimensional time-harmonic Maxwell equations
Developing Secure Systems: A Comparative Study of Existing Methodologies
Does Foreign Ownership Influence Firm Profitability? Evidence from the Tunisian Context
Development of nano-crosslinked polyacrylonitrile ions exchanger particles for dyes removal
DT-DT: Top-down Human Activity Analysis for Interactive Surface Applications
DFT calculations, spectroscopic, thermal analysis and biological activity of Sm (III) and Tb (III) complexes with 2-aminobenzoic and 2-amino-5-chloro-benzoic acids
Distributions covariantes sur les espaces hyperboliques
Determination of Ofloxacin using a Highly Selective Photo Probe Based on the Enhancement of the Luminescence Intensity of Eu3+—Ofloxacin Complex in Pharmaceutical and Serum Samples