Publications
Innovation, Crude Oil Prices, Fossil Fuel Energy Consumption and Climate Sustainability in Egypt: Using the Gradient Boosting Machine Learning Algorithm
Integrating hydrogeochemical analysis and machine learning to assess surface–groundwater interactions in an arid basin (Middle Egypt)
Identification of bioactive phytoconstituents as promising ABL2 inhibitors using virtual screening and molecular dynamics simulation
In-silico studies, synthesis, and pharmacological screening of novel multitarget diphenylpyrazole scaffold as EGFR/BRAF and cyclooxygenase-2 inhibitors
In-silico studies, synthesis, and pharmacological screening of novel multitarget diphenylpyrazole scaffold as EGFR/BRAF and cyclooxygenase-2 inhibitors
Impact of AI Transformation, Financial Inclusion, and Operational Efficiency on Global Economic Growth: Dynamic GMM Approach
Impact of AI Transformation, Financial Inclusion, and Operational Efficiency on Global Economic Growth: Dynamic GMM Approach
In-silico studies, synthesis, and pharmacological screening of novel multitarget diphenylpyrazole scaffold as EGFR/BRAF and cyclooxygenase-2 inhibitors
Integrating AI chatbots for enhancing academic support in business education: A SEM-Based study toward sustainable learning
Innovative an aqueous solution-based approach for the preparation of modified borate glass-ceramic: Structural and thermal evolution
Interleukin-32: a Pandora’s box in human immunodeficiency virus infection
Interleukin-32: a Pandora’s box in human immunodeficiency virus infection
Interleukin-32: a Pandora's box in human immunodeficiency virus infection
Interactions amongst macro-economic variables: New global evidences
Impact on Human Mental Behavior After Retirement Using Supervised Machine Learning Based on Decision Tree and Neural Network
Integrating Solar Energy in Urban Development: Strategies for Sustainable and Smart Cities
Interfacial Engineering of Titanium Carbide (Ti₃C₂Tₓ) MXene and Samarium Cobalt Phosphate (SmCoPO₄) Nanostructures Boosts Charge Storage in Hybrid Supercapacitors
In vitro investigation of Datura innoxia phytocompounds against Mycobacterium tuberculosis H37Ra strain in association with in silico studiesuberculosis (TB) is a recurrent and progressive bacterial disease caused by Mycobacterium tuberculosis (Mtb), posing a significant challenge globally due to its drug resistance. This study focuses on identifying natural phytocompounds from the plant Datura innoxia (leaves), which is well known for its biologically active metabolites. Initially, the current study employed in vitro analysis of 20 phytocompounds, revealing that the natural compound 9, o-vanillin, exhibited the best minimal inhibitory concentration (MIC) which was 12.5 µg/mL, and minimal bactericidal concentration (MBC) was 50 µg/mL, all other phytocompounds showing remarkable antitubercular activity against the Mtb H37Ra strain. The molecular docking and simulation also validated the strong affinity and stable binding interactions between compound 9 and target protein kinase. The pharmacokinetic analysis highlighted the suitable oral bioavailability and no significant CYP450 inhibition for the lead compound 9, reducing the risk for drug-drug interactions. Moreover, the density functional theory analysis of lead compound 9 demonstrated optimal molecular properties, further contributing to the chemical stability and reactivity. Therefore, these results suggest that D. innoxia contains the potent phytocompound o-vanillin, which possesses antitubercular activity and can potentially be used as a drug against TB. However, future studies will focus on in vivo validation and formulation development for clinical applications.
Innovative an aqueous solution-based approach for the preparation of modified borate glass-ceramic: Structural and thermal evolution
Integrating dynamic water ecosystem changes and socio-cultural metrics for wastewater plant siting: A machine learning approach
Interfacial engineering of titanium carbide (Ti₃C₂Tₓ) MXene and samarium cobalt phosphate (SmCoPO₄) nanostructures boosts charge storage in hybrid supercapacitors
Interfacial Engineering of Titanium Carbide (Ti₃C₂Tₓ) MXene and Samarium Cobalt Phosphate (SmCoPO₄) Nanostructures Boosts Charge Storage in Hybrid Supercapacitors
Interfacial Engineering of Titanium Carbide (Ti₃C₂Tₓ) MXene and Samarium Cobalt Phosphate (SmCoPO₄) Nanostructures Boosts Charge Storage in Hybrid Supercapacitors
Influence of clinical practice stressors on critical care nursing student’s burnout: Resilience as a mediating factor
Innovative Amino-Functionalization of Pyrido[2,3-d]pyrimidine Scaffolds for Broad Therapeutic Applications Supported by Computational Analyses
Interfacial Engineering of Titanium Carbide (Ti₃C₂Tₓ) MXene and Samarium Cobalt Phosphate (SmCoPO₄) Nanostructures Boosts Charge Storage in Hybrid Supercapacitors
In vitro antiviral activities of thymol and Limonin against influenza a viruses and SARS-CoV-2
Innovative medical imaging using photonic crystal fiber photodetector (PCFP) with Ultra-High efficiency for pregnancy testing
Innovative an aqueous solution-based approach for the preparation of modified borate glass-ceramic: structural and thermal evolution
Inviscid Limit For The Sub-Critical Dissipative Quasi-Geostrophic Equations In The Sobolev Spaces
Investigating the Adsorption and Electronic Properties of Hydroxyurea on Pristine and Carbon Doped B24N24 Nanocages
Investigating the Adsorption and Electronic Properties of Hydroxyurea on Pristine and Carbon Doped B24N24 Nanocages
Investigating the Adsorption and Electronic Properties of Hydroxyurea on Pristine and Carbon Doped B24N24 Nanocages
Investigating the Adsorption and Electronic Properties of Hydroxyurea on Pristine and Carbon Doped B24N24 Nanocages
Influence of internal heat source and temperature-dependent effects on thermoelasticity within Lord-Shulman framework using modified extended direct algebraic approach
Integration of graph neural networks and long short-term memory models for advancing heart failure prediction
Integrative review of artificial intelligence applications in nursing: education, clinical practice, workload management, and professional perceptions
Integrating Artificial Intelligence into Perinatal Care Pathways: A Scoping Review of Reviews of Applications, Outcomes, and Equity
Interpretable graph Kolmogorov–Arnold networks for multi-cancer classification and biomarker identification using multi-omics data
Investigating the Diagnostic Utility of LncRNA GAS5 in NAFLD Patients
Identification and evaluation of pyrimidine based CDK6 inhibitors against glioblastoma using integrated computational approaches
Identification and evaluation of pyrimidine based CDK6 inhibitors against glioblastoma using integrated computational approaches.
Influence of clinical practice stressors on critical care nursing student’s burnout: Resilience as a mediating factor
Investigation of magneto–thermoelastic effects in a perfectly conducting micropolar half-space using nonlocal theory with internal length and time scales
Inorganic-Organic-Based Hybrid Sensors for Water Purification: A Review on the Optical Detection and Adsorption of Cadmium and Chromium Ions
Inorganic-Organic-Based Hybrid Sensors for Water Purification: A Review on the Optical Detection and Adsorption of Cadmium and Chromium Ions
Influence of Post-Printing Polymerization Time on the Elution of Residual Monomers and Water Sorption of 3D-Printed Resin Composite
Impact of Data Balancing and Feature Engineering on Accident Severity Models
Investigation of scale parameter for the Weibull-Chen distribution
Information-Theoretic Reliability Analysis of Linear Consecutive r-out-of-n:F Systems and Uniformity Testing
Investigation of entropy generation in the magnetohydrodynamic electroosmotic peristaltic flow of Cu-Al2O3/H2O hybrid nanofluid via a curved channel
In Vitro and In Vivo Appraisal of Glycerylmonostearate/chitosan Hybrid Nanocapsules As Peroral Delivery System of Simvastatin
Innovative experimental and theoretical strategies for sustainable heavy metal ion removal using chitosan@TiO2 composites functionalized with nanostructured metal oxides
In Vitro and In Vivo Appraisal of Glycerylmonostearate/chitosan Hybrid Nanocapsules As Peroral Delivery System of Simvastatin
In Vitro and In Vivo Appraisal of Glycerylmonostearate/chitosan Hybrid Nanocapsules As Peroral Delivery System of Simvastatin
In Vitro and In Vivo Appraisal of Glycerylmonostearate/chitosan Hybrid Nanocapsules As Peroral Delivery System of Simvastatin
Innovative strategies in the diagnosis and treatment of liver cirrhosis and associated syndromes
Integration of graph neural networks and long short-term memory models for advancing heart failure prediction
Identification of Bacterial Oligopeptidase B Inhibitors from Microbial Natural Products: Molecular Insights, Docking Studies, MD Simulations, and ADMET Predictions
Identification of Bacterial Oligopeptidase B Inhibitors from Microbial Natural Products: Molecular Insights, Docking Studies, MD Simulations, and ADMET Predictions
Investigation of the optical modal gain in an InAsP/AlGaInP quantum dot laser diode structure
Improving energy efficiency and routing reliability in wireless sensor networks using modified ant colony optimization
Integrating sentiment analysis with machine learning for cyberbullying detection on social media
Insights into coupling effects of double light square bubbles on shocked hydrodynamic instability
Improved healthcare diagnosis accuracy through the application of deep learning techniques in medical transcription for disease identification
Influence of oromotor functions on motor development and feeding outcomes in children with cerebral palsy
Innovative Tailored Semantic Embedding and Machine Learning for Precise Prediction of Drug-Drug Interaction Seriousness
Innovative Tailored Semantic Embedding and Machine Learning for Precise Prediction of Drug-Drug Interaction Seriousness
Integrated Electrically Small Monopole and Slotted Array Antenna Design for Next-Generation Microwave and mm-wave Wireless Systems
Insights into New Generalization of q-Legendre-Based Appell Polynomials: Properties and Quasi Monomiality
Isoflavones: Promising Natural Agent for CancerPrevention and Treatment
initio investigation for π-hole interactions of tetrel- and aerogen-bearing molecules with multiple CO Lewis bases
Intergenerational Relationships and Their Impact on Social Resilience Amongst Arab Society Elderly Populations: A Qualitative Exploration
Investigating root and canal morphology of anterior and premolar teeth using CBCT with a novel coding classification system in Saudi subpopulation
Insights into the electronic, mechanical and thermodynamic properties of pyrochlore oxides A2B2O7: A first-principles study
In silico development of potential InhA inhibitors through 3D-QSAR analysis, virtual screening and molecular dynamics
In silico identification and characterization of potent laccase inhibitors against Cryptococcus neoformans: A multi-scale computational study
In silico identification and characterization of potent laccase inhibitors against Cryptococcus neoformans: A multi-scale computational study
In silico identification and characterization of potent laccase inhibitors against Cryptococcus neoformans: A multi-scale computational study
Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss
Isatin derived morpholine and piperazine derivatives as acetylcholinesterase inhibitors
Identifying novel inhibitors against drug-resistant mutant CYP-51 Candida albicans: A computational study to combat fungal infections
Identifying novel inhibitors against drug-resistant mutant CYP-51 Candida albicans: A computational study to combat fungal infections
Intrusion detection in smart grids using artificial intelligence-based ensemble modelling
In silico evaluation of snake venom proteins against multidrug-resistant Mycobacterium tuberculosis: A molecular dynamics study and simulation dynamic
Investigation of structural and optical properties of Ni+2 ions-bearing borate glass through barium ions addition
Improved MPPT of Solar PV Systems under different Environmental conditions utilizes a Novel Hybrid PSO
Improved Capacity and Security in Text Steganography Using the Double Secure Algorithm (DSTS)
Intrusion detection in smart grids using artificial intelligence-based ensemble modelling
Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss
Improved MPPT of solar PV Systems under different Environmental conditions utilizes a Novel Hybrid PSO
In silico and in vivo evaluation of erucic acid against pentylenetetrazole-induced seizures in mice by modulating oxidative stress, neurotransmitters and neuroinflammation markersPen
Influence of bio-filter configurations on hydraulic aspects while enhancing the sustainable self-purification of agricultural drainage water
Impact of ZrO₂ nanoparticles on surface, thermal, and structural properties of PVA/ZrO₂ composite films for advanced flexible electronics applications
Influence of Post-Printing Polymerization Time on Flexural Strength and Microhardness of 3D Printed Resin Composite
Investigation of Machine Learning Optimized Graphene-Based Ultrabroadband Plasmonic Solar Thermal Absorber for Renewable Energy Applications
Influence of ZrO₂ Nanoparticles on Surface, Thermal, and Structural Properties of PVA/ZrO₂ Composite Films for Advanced Flexible Electronics Applications
INF-γ/TGF-β1-primed umbilical cord mesenchymal stem cells boost the T-lymphocytes activity: Modulation of CD25 expression and IL-6 secretion
Intelligent decision support framework for assessment of alternative vehicle technologies in transportation system: A sustainable approach toward environmental remedy
Influence of silver nanoparticles on the surface characteristics and electrical properties of polypyrrole/PET polymeric composite films for electronic devices
Innovative Diagnostic Approaches and Challenges in the ManagementofHIV:Bridging Basic Science and Clinical Practice
Influence of bio-filter configurations on hydraulic aspects while enhancing the sustainable self-purification of agricultural drainage water
Investigation of Graphene‑Based Multilayer Zr‑GaSb‑TiC Wide‑Band Surface Plasmon Resonance Solar Absorber for Renewable Energy Applications Optimized Using Machine Learning
Influence of zinc acetate on HPMC/CMC polymer blend: Investigation of their composites’ structural, optical, and dielectric properties for dielectric capacitor applications
Identification of key signaling pathways and novel computational drug target for oral cancer, metabolic disorders and periodontal disease Author links open overlay panel
Ionizing radiation shielding properties of CdZnSe chalcogenide glass
Irreversibility analysis of bio-convection nanofluid flow in a Darcy-Forchheimer porous medium induced by a rotating disk with thermal radiation
Impact of Fe(III) and Ce(III) ions on pharmacological properties of novel Schiff base ligand: Anticancer, antiviral, antioxidant, anti-fungal investigations from wallpaper, and computational insights
Improving the efficiency of polymer solar cells based on chitosan@PVA@rGO composites via gamma-irradiated treatment of rGO nanoparticles
DOI: https://doi.org/10.1016/j.solidstatesciences.2024.107773
Investigation of spin polarized semiconductor Cs2XMoBr6 (X= Li, Na) compounds for spintronic and optoelectronic applications